TY - JOUR
T1 - Surgical antibiotic prophylaxis in an era of antibiotic resistance
T2 - common resistant bacteria and wider considerations for practice
AU - Menz, Bradley D.
AU - Charani, Esmita
AU - Gordon, David L.
AU - Leather, Andrew J.M.
AU - Ramani Moonesinghe, S.
AU - Phillips, Cameron J.
N1 - Funding Information:
EC, AL and RM acknowledge funding from the Economic and Social Research Council (ESRC) and the National Institute for Health Research ASPIRES project (Antibiotic use across Surgical Pathways: Investigating, Redesigning and Evaluating Systems) (https://www.imper ial.ac.uk/arc/aspires/). ASPIRES aims to address antimicrobial resistance and improve clinical outcomes optimising antibiotic usage along surgical pathways. EC acknowledges the National Institute for Health Research, UK Department of Health [HPRU-2012-10047] in partnership with Public Health England. The funders had no role in the design and conduct of this review; collection, management, analysis, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Funding Information:
Dr Esmita Charani reports personal fees from Pfizer, outside the submitted work. Dr Andrew JM Leather reports grants from Economic and Social Research Council (ESRC). The authors report no other conflicts of interest in this work.
Funding Information:
EC, AL and RM acknowledge funding from the Economic and Social Research Council (ESRC) and the National Institute for Health Research ASPIRES project
Publisher Copyright:
© 2021 Menz et al. This work is published and licensed by Dove Medical Press Limited.
PY - 2021
Y1 - 2021
N2 - The increasing incidence of antimicrobial resistance (AMR) presents a global crisis to healthcare, with longstanding antimicrobial agents becoming less effective at treating and preventing infection. In the surgical setting, antibiotic prophylaxis has long been established as routine standard of care to prevent surgical site infection (SSI), which remains one of the most common hospital-acquired infections. The growing incidence of AMR increases the risk of SSI complicated with resistant bacteria, resulting in poorer surgical outcomes (prolonged hospitalisation, extended durations of antibiotic therapy, higher rates of surgical revision and mortality). Despite these increasing challenges, more data are required on approaches at the institutional and patient level to optimise surgical antibiotic prophylaxis in the era of antibiotic resistance (AR). This review provides an overview of the common resistant bacteria encountered in the surgical setting and covers wider considerations for practice to optimise surgical antibiotic prophylaxis in the perioperative setting.
AB - The increasing incidence of antimicrobial resistance (AMR) presents a global crisis to healthcare, with longstanding antimicrobial agents becoming less effective at treating and preventing infection. In the surgical setting, antibiotic prophylaxis has long been established as routine standard of care to prevent surgical site infection (SSI), which remains one of the most common hospital-acquired infections. The growing incidence of AMR increases the risk of SSI complicated with resistant bacteria, resulting in poorer surgical outcomes (prolonged hospitalisation, extended durations of antibiotic therapy, higher rates of surgical revision and mortality). Despite these increasing challenges, more data are required on approaches at the institutional and patient level to optimise surgical antibiotic prophylaxis in the era of antibiotic resistance (AR). This review provides an overview of the common resistant bacteria encountered in the surgical setting and covers wider considerations for practice to optimise surgical antibiotic prophylaxis in the perioperative setting.
KW - Antibiotic resistance
KW - Antimicrobial stewardship
KW - Perioperative care
KW - Surgical antibiotic prophylaxis
KW - Surgical site infection
UR - http://www.scopus.com/inward/record.url?scp=85120798368&partnerID=8YFLogxK
U2 - 10.2147/IDR.S319780
DO - 10.2147/IDR.S319780
M3 - Review article
AN - SCOPUS:85120798368
SN - 1178-6973
VL - 14
SP - 5235
EP - 5252
JO - Infection and Drug Resistance
JF - Infection and Drug Resistance
ER -
