Testing replication of a 5-SNP set for general cognitive ability in six population samples

Michelle Luciano; Penelope A. Lind; Ian J. Deary; Antony Payton; Danielle Posthuma; Lee M. Butcher; Zoltan Bochdanovits; Lawrence J. Whalley; Peter M. Visscher; Sarah E. Harris; Tinca J. C. Polderman; Oliver S. P. Davis; Margaret J. Wright; John M. Starr; Eco J. C. de Geus; Timothy C. Bates; Grant W. Montgomery; Dorret I. Boomsma; Nicholas G. Martin; Robert Plomin

doi:10.1038/ejhg.2008.100

Testing replication of a 5-SNP set for general cognitive ability in six population samples

Michelle Luciano, Penelope A. Lind, Ian J. Deary, Antony Payton, Danielle Posthuma, Lee M. Butcher, Zoltan Bochdanovits, Lawrence J. Whalley, Peter M. Visscher, Sarah E. Harris, Tinca J. C. Polderman, Oliver S. P. Davis, Margaret J. Wright, John M. Starr, Eco J. C. de Geus, Timothy C. Bates, Grant W. Montgomery, Dorret I. Boomsma, Nicholas G. Martin, Robert Plomin

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

Original language	English
Pages (from-to)	1388 - 1395
Number of pages	8
Journal	European Journal of Human Genetics
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/ejhg.2008.100
Publication status	Published - 2008

Keywords

SNP set
Cognitive ability
Replication

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10.1038/ejhg.2008.100

Origins of learning difficulties and behaviour problems: From behavioural genetics to behavioural genomics
Plomin, R. (Primary Investigator)
MRC Medical Research Council
1/10/2005 → 30/09/2010
Project: Research

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Luciano, M., Lind, P. A., Deary, I. J., Payton, A., Posthuma, D., Butcher, L. M., Bochdanovits, Z., Whalley, L. J., Visscher, P. M., Harris, S. E., Polderman, T. J. C., Davis, O. S. P., Wright, M. J., Starr, J. M., de Geus, E. J. C., Bates, T. C., Montgomery, G. W., Boomsma, D. I., Martin, N. G., & Plomin, R. (2008). Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16(11), 1388 - 1395. https://doi.org/10.1038/ejhg.2008.100

@article{71f84cd2c9d64726a29cdb3efcf38fac,

title = "Testing replication of a 5-SNP set for general cognitive ability in six population samples",

abstract = "A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008",

keywords = "SNP set, Cognitive ability, Replication",

author = "Michelle Luciano and Lind, {Penelope A.} and Deary, {Ian J.} and Antony Payton and Danielle Posthuma and Butcher, {Lee M.} and Zoltan Bochdanovits and Whalley, {Lawrence J.} and Visscher, {Peter M.} and Harris, {Sarah E.} and Polderman, {Tinca J. C.} and Davis, {Oliver S. P.} and Wright, {Margaret J.} and Starr, {John M.} and {de Geus}, {Eco J. C.} and Bates, {Timothy C.} and Montgomery, {Grant W.} and Boomsma, {Dorret I.} and Martin, {Nicholas G.} and Robert Plomin",

year = "2008",

doi = "10.1038/ejhg.2008.100",

language = "English",

volume = "16",

pages = "1388 -- 1395",

journal = "European Journal of Human Genetics",

publisher = "Nature Publishing Group",

number = "11",

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Luciano, M, Lind, PA, Deary, IJ, Payton, A, Posthuma, D, Butcher, LM, Bochdanovits, Z, Whalley, LJ, Visscher, PM, Harris, SE, Polderman, TJC, Davis, OSP, Wright, MJ, Starr, JM, de Geus, EJC, Bates, TC, Montgomery, GW, Boomsma, DI, Martin, NG & Plomin, R 2008, 'Testing replication of a 5-SNP set for general cognitive ability in six population samples', European Journal of Human Genetics, vol. 16, no. 11, pp. 1388 - 1395. https://doi.org/10.1038/ejhg.2008.100

TY - JOUR

T1 - Testing replication of a 5-SNP set for general cognitive ability in six population samples

AU - Luciano, Michelle

AU - Lind, Penelope A.

AU - Deary, Ian J.

AU - Payton, Antony

AU - Posthuma, Danielle

AU - Butcher, Lee M.

AU - Bochdanovits, Zoltan

AU - Whalley, Lawrence J.

AU - Visscher, Peter M.

AU - Harris, Sarah E.

AU - Polderman, Tinca J. C.

AU - Davis, Oliver S. P.

AU - Wright, Margaret J.

AU - Starr, John M.

AU - de Geus, Eco J. C.

AU - Bates, Timothy C.

AU - Montgomery, Grant W.

AU - Boomsma, Dorret I.

AU - Martin, Nicholas G.

AU - Plomin, Robert

PY - 2008

Y1 - 2008

N2 - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

AB - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

KW - SNP set

KW - Cognitive ability

KW - Replication

U2 - 10.1038/ejhg.2008.100

DO - 10.1038/ejhg.2008.100

M3 - Article

VL - 16

SP - 1388

EP - 1395

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 11

ER -

Testing replication of a 5-SNP set for general cognitive ability in six population samples

Abstract

Keywords

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Projects

Origins of learning difficulties and behaviour problems: From behavioural genetics to behavioural genomics

Cite this