The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom

Ines Zimbarra Cabrita; Abubakar Mohammed; Mark Layton; Sara Ghorashian; Annette Gilmore; Gavin Cho; Jo Howard; Kofi A. Anie; Lynda Desforges; Paul Bassett; Julia Grapsa; Luke Howard; Gaia Mahalingam; David Dawson; Fausto J. Pinto; Petros Nihoyannopoulos; Sally C. Davies; J. Simon R. Gibbs

doi:10.1111/bjh.12391

The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom

Ines Zimbarra Cabrita, Abubakar Mohammed, Mark Layton, Sara Ghorashian, Annette Gilmore, Gavin Cho, Jo Howard, Kofi A. Anie, Lynda Desforges, Paul Bassett, Julia Grapsa, Luke Howard, Gaia Mahalingam, David Dawson, Fausto J. Pinto, Petros Nihoyannopoulos, Sally C. Davies, J. Simon R. Gibbs^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet >= 2 center dot 5m/s on echocardiography. Elevated TRV was present in 29 center dot 1% of patients and it was associated with increased age and left atrial diameter.There were 15 deaths (9 center dot 1%) over a median of 68 center dot 1 months follow up; seven patients had increased TRV, and eight patients had a TRV

Original language	English
Pages (from-to)	400-408
Number of pages	9
Journal	British Journal of Haematology
Volume	162
Issue number	3
DOIs	https://doi.org/10.1111/bjh.12391
Publication status	Published - Aug 2013

Keywords

sickle cell disease
pulmonary hypertension
mortality
survival
tricuspid regurgitation velocity
OF-ECHOCARDIOGRAPHYS GUIDELINES
PULMONARY-HYPERTENSION
STANDARDS COMMITTEE
SYSTOLIC PRESSURE
TASK-FORCE
RECOMMENDATIONS
MORTALITY
CHILDREN
RISK
CATHETERIZATION

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10.1111/bjh.12391

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Cabrita, I. Z., Mohammed, A., Layton, M., Ghorashian, S., Gilmore, A., Cho, G., Howard, J., Anie, K. A., Desforges, L., Bassett, P., Grapsa, J., Howard, L., Mahalingam, G., Dawson, D., Pinto, F. J., Nihoyannopoulos, P., Davies, S. C., & Gibbs, J. S. R. (2013). The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom. British Journal of Haematology, 162(3), 400-408. https://doi.org/10.1111/bjh.12391

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title = "The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom",

abstract = "Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet >= 2 center dot 5m/s on echocardiography. Elevated TRV was present in 29 center dot 1% of patients and it was associated with increased age and left atrial diameter.There were 15 deaths (9 center dot 1%) over a median of 68 center dot 1 months follow up; seven patients had increased TRV, and eight patients had a TRV",

keywords = "sickle cell disease, pulmonary hypertension, mortality, survival, tricuspid regurgitation velocity, OF-ECHOCARDIOGRAPHYS GUIDELINES, PULMONARY-HYPERTENSION, STANDARDS COMMITTEE, SYSTOLIC PRESSURE, TASK-FORCE, RECOMMENDATIONS, MORTALITY, CHILDREN, RISK, CATHETERIZATION",

author = "Cabrita, {Ines Zimbarra} and Abubakar Mohammed and Mark Layton and Sara Ghorashian and Annette Gilmore and Gavin Cho and Jo Howard and Anie, {Kofi A.} and Lynda Desforges and Paul Bassett and Julia Grapsa and Luke Howard and Gaia Mahalingam and David Dawson and Pinto, {Fausto J.} and Petros Nihoyannopoulos and Davies, {Sally C.} and Gibbs, {J. Simon R.}",

year = "2013",

month = aug,

doi = "10.1111/bjh.12391",

language = "English",

volume = "162",

pages = "400--408",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

Cabrita, IZ, Mohammed, A, Layton, M, Ghorashian, S, Gilmore, A, Cho, G, Howard, J, Anie, KA, Desforges, L, Bassett, P, Grapsa, J, Howard, L, Mahalingam, G, Dawson, D, Pinto, FJ, Nihoyannopoulos, P, Davies, SC & Gibbs, JSR 2013, 'The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom', British Journal of Haematology, vol. 162, no. 3, pp. 400-408. https://doi.org/10.1111/bjh.12391

The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom. / Cabrita, Ines Zimbarra; Mohammed, Abubakar; Layton, Mark et al.
In: British Journal of Haematology, Vol. 162, No. 3, 08.2013, p. 400-408.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom

AU - Cabrita, Ines Zimbarra

AU - Mohammed, Abubakar

AU - Layton, Mark

AU - Ghorashian, Sara

AU - Gilmore, Annette

AU - Cho, Gavin

AU - Howard, Jo

AU - Anie, Kofi A.

AU - Desforges, Lynda

AU - Bassett, Paul

AU - Grapsa, Julia

AU - Howard, Luke

AU - Mahalingam, Gaia

AU - Dawson, David

AU - Pinto, Fausto J.

AU - Nihoyannopoulos, Petros

AU - Davies, Sally C.

AU - Gibbs, J. Simon R.

PY - 2013/8

Y1 - 2013/8

N2 - Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet >= 2 center dot 5m/s on echocardiography. Elevated TRV was present in 29 center dot 1% of patients and it was associated with increased age and left atrial diameter.There were 15 deaths (9 center dot 1%) over a median of 68 center dot 1 months follow up; seven patients had increased TRV, and eight patients had a TRV

AB - Raised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet >= 2 center dot 5m/s on echocardiography. Elevated TRV was present in 29 center dot 1% of patients and it was associated with increased age and left atrial diameter.There were 15 deaths (9 center dot 1%) over a median of 68 center dot 1 months follow up; seven patients had increased TRV, and eight patients had a TRV

KW - sickle cell disease

KW - pulmonary hypertension

KW - mortality

KW - survival

KW - tricuspid regurgitation velocity

KW - OF-ECHOCARDIOGRAPHYS GUIDELINES

KW - PULMONARY-HYPERTENSION

KW - STANDARDS COMMITTEE

KW - SYSTOLIC PRESSURE

KW - TASK-FORCE

KW - RECOMMENDATIONS

KW - MORTALITY

KW - CHILDREN

KW - RISK

KW - CATHETERIZATION

U2 - 10.1111/bjh.12391

DO - 10.1111/bjh.12391

M3 - Article

SN - 0007-1048

VL - 162

SP - 400

EP - 408

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom

Abstract

Keywords

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