The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Annika Brosig; Joachim Fuchs; Fatih Ipek; Cristina Kroon; Sandra Schrötter; Mayur Vadhvani; Alexandra Polyzou; Julia Ledderose; Michiel van Diepen; Hermann Georg Holzhütter; Thorsten Trimbuch; Niclas Gimber; Jan Schmoranzer; Ivo Lieberam; Christian Rosenmund; Christian Spahn; Patrick Scheerer; Michal Szczepek; George Leondaritis; Britta J. Eickholt

doi:10.1016/j.celrep.2019.10.039

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Annika Brosig, Joachim Fuchs, Fatih Ipek, Cristina Kroon, Sandra Schrötter, Mayur Vadhvani, Alexandra Polyzou, Julia Ledderose, Michiel van Diepen, Hermann Georg Holzhütter, Thorsten Trimbuch, Niclas Gimber, Jan Schmoranzer, Ivo Lieberam, Christian Rosenmund, Christian Spahn, Patrick Scheerer, Michal Szczepek, George Leondaritis^*, Britta J. Eickholt

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.

Original language	English
Pages (from-to)	2028-2040.e8
Journal	Cell Reports
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2019.10.039
Publication status	Published - 12 Nov 2019

Keywords

axon morphogenesis
branching
neuronal growth homeostasis
phosphoinositide signaling
PI3K signaling
plasticity-related gene family
PTEN

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10.1016/j.celrep.2019.10.039

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Brosig, A., Fuchs, J., Ipek, F., Kroon, C., Schrötter, S., Vadhvani, M., Polyzou, A., Ledderose, J., van Diepen, M., Holzhütter, H. G., Trimbuch, T., Gimber, N., Schmoranzer, J., Lieberam, I., Rosenmund, C., Spahn, C., Scheerer, P., Szczepek, M., Leondaritis, G., & Eickholt, B. J. (2019). The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Reports, 29(7), 2028-2040.e8. https://doi.org/10.1016/j.celrep.2019.10.039

@article{740f9ce7e4544c39a73ab746645ce5d0,

title = "The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches",

abstract = "PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.",

keywords = "axon morphogenesis, branching, neuronal growth homeostasis, phosphoinositide signaling, PI3K signaling, plasticity-related gene family, PTEN",

author = "Annika Brosig and Joachim Fuchs and Fatih Ipek and Cristina Kroon and Sandra Schr{\"o}tter and Mayur Vadhvani and Alexandra Polyzou and Julia Ledderose and {van Diepen}, Michiel and Holzh{\"u}tter, {Hermann Georg} and Thorsten Trimbuch and Niclas Gimber and Jan Schmoranzer and Ivo Lieberam and Christian Rosenmund and Christian Spahn and Patrick Scheerer and Michal Szczepek and George Leondaritis and Eickholt, {Britta J.}",

year = "2019",

month = nov,

day = "12",

doi = "10.1016/j.celrep.2019.10.039",

language = "English",

volume = "29",

pages = "2028--2040.e8",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

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}

Brosig, A, Fuchs, J, Ipek, F, Kroon, C, Schrötter, S, Vadhvani, M, Polyzou, A, Ledderose, J, van Diepen, M, Holzhütter, HG, Trimbuch, T, Gimber, N, Schmoranzer, J, Lieberam, I, Rosenmund, C, Spahn, C, Scheerer, P, Szczepek, M, Leondaritis, G & Eickholt, BJ 2019, 'The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches', Cell Reports, vol. 29, no. 7, pp. 2028-2040.e8. https://doi.org/10.1016/j.celrep.2019.10.039

TY - JOUR

T1 - The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

AU - Brosig, Annika

AU - Fuchs, Joachim

AU - Ipek, Fatih

AU - Kroon, Cristina

AU - Schrötter, Sandra

AU - Vadhvani, Mayur

AU - Polyzou, Alexandra

AU - Ledderose, Julia

AU - van Diepen, Michiel

AU - Holzhütter, Hermann Georg

AU - Trimbuch, Thorsten

AU - Gimber, Niclas

AU - Schmoranzer, Jan

AU - Lieberam, Ivo

AU - Rosenmund, Christian

AU - Spahn, Christian

AU - Scheerer, Patrick

AU - Szczepek, Michal

AU - Leondaritis, George

AU - Eickholt, Britta J.

PY - 2019/11/12

Y1 - 2019/11/12

N2 - PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.

AB - PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.

KW - axon morphogenesis

KW - branching

KW - neuronal growth homeostasis

KW - phosphoinositide signaling

KW - PI3K signaling

KW - plasticity-related gene family

KW - PTEN

UR - http://www.scopus.com/inward/record.url?scp=85074665992&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.10.039

DO - 10.1016/j.celrep.2019.10.039

M3 - Article

C2 - 31722215

AN - SCOPUS:85074665992

SN - 2211-1247

VL - 29

SP - 2028-2040.e8

JO - Cell Reports

JF - Cell Reports

IS - 7

ER -

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

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