TY - JOUR
T1 - The dopaminergic basis of cognitive and motor performance in Alzheimer's disease
AU - Reeves, Suzanne
AU - Mehta, Mitul
AU - Howard, Robert
AU - Grasby, Paul
AU - Brown, Richard
PY - 2010/2
Y1 - 2010/2
N2 - A crucial role of corticostriatal dopaminergic networks in cognitive and motor processes has been well established but largely unexplored in Alzheimer's disease (AD). The study investigated the relationship between striatal DA (D-2) receptor availability and specific aspects of cognitive (sustained visual attention, spatial planning, word recognition) and motor (speed and dexterity) function in 24 people with mild to moderate AD. In vivo clopamine DA (D-2) receptor availability was determined with [C-11] raclopride (RAC) positron emission tomography (PET). Imaging data were analysed using both region of interest (ROI) and voxel-based approaches. Higher [C-11] RAC binding was associated with increased motor speed and, paradoxically, poorer attentional performance. These findings are broadly consistent with previously conducted studies in healthy older adults and would suggest that the use of DA (D-2) receptor agonists as an adjunctive treatment strategy in AD may have dissociable effects upon cognitive function. (C) 2009 Elsevier Inc. All rights reserved.
AB - A crucial role of corticostriatal dopaminergic networks in cognitive and motor processes has been well established but largely unexplored in Alzheimer's disease (AD). The study investigated the relationship between striatal DA (D-2) receptor availability and specific aspects of cognitive (sustained visual attention, spatial planning, word recognition) and motor (speed and dexterity) function in 24 people with mild to moderate AD. In vivo clopamine DA (D-2) receptor availability was determined with [C-11] raclopride (RAC) positron emission tomography (PET). Imaging data were analysed using both region of interest (ROI) and voxel-based approaches. Higher [C-11] RAC binding was associated with increased motor speed and, paradoxically, poorer attentional performance. These findings are broadly consistent with previously conducted studies in healthy older adults and would suggest that the use of DA (D-2) receptor agonists as an adjunctive treatment strategy in AD may have dissociable effects upon cognitive function. (C) 2009 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.nbd.2009.11.005
DO - 10.1016/j.nbd.2009.11.005
M3 - Article
VL - 37
SP - 477
EP - 482
JO - Neurobiology of Disease
JF - Neurobiology of Disease
IS - 2
ER -