TY - JOUR
T1 - The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes
AU - Alam, S
AU - Stolinski, M
AU - Pentecost, C
AU - Boroujerdi, M A
AU - Jones, R H
AU - Sonksen, P H
AU - Umpleby, A M
PY - 2004/2
Y1 - 2004/2
N2 - The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program. Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P <0.001), body fat (P <0.004), nonesterified fatty acid (P <0.04), and triglycerides (P <0.05) and an increase in insulin sensitivity (P <0.01). There was a decrease in VLDL apoB pool size (160.8 &PLUSMN; 42.6 to 84.9 &PLUSMN; 23.2 mg, P <0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P <0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.
AB - The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program. Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P <0.001), body fat (P <0.004), nonesterified fatty acid (P <0.04), and triglycerides (P <0.05) and an increase in insulin sensitivity (P <0.01). There was a decrease in VLDL apoB pool size (160.8 &PLUSMN; 42.6 to 84.9 &PLUSMN; 23.2 mg, P <0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P <0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.
UR - http://www.scopus.com/inward/record.url?scp=1442303359&partnerID=8YFLogxK
U2 - 10.1210/jc.2003-031036
DO - 10.1210/jc.2003-031036
M3 - Article
SN - 1945-7197
VL - 89
SP - 688
EP - 694
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 2
ER -
