The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M Thompson; Jason L Stein; Sarah E Medland; Derrek P Hibar; Alejandro Arias Vasquez; Miguel E Renteria; Roberto Toro; Neda Jahanshad; Gunter Schumann; Barbara Franke; Margaret J Wright; Nicholas G Martin; Ingrid Agartz; Martin Alda; Saud Alhusaini; Laura Almasy; Jorge Almeida; Kathryn Alpert; Nancy C Andreasen; Ole A Andreassen; Liana G Apostolova; Katja Appel; Nicola J Armstrong; Benjamin Aribisala; Mark E Bastin; Michael Bauer; Carrie E Bearden; Orjan Bergmann; Elisabeth B Binder; John Blangero; Henry J Bockholt; Erlend Bøen; Catherine Bois; Dorret I Boomsma; Patricia Conrod; Giuseppe Delvecchio; Danai Dima; Rali Dimitrova; Sophia Frangou; Eva Loth; Anbarasu Lourdusamy; Colm McDonald; Mary Phillips; Adaikalavan Ramasamy; Cathy Scanlon; Andrew Simmons; Robert Walker; Michael E Weale; Peter R Schofield; Natalia S Lawrence; the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group

doi:10.1007/s11682-013-9269-5

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M Thompson, Jason L Stein, Sarah E Medland, Derrek P Hibar, Alejandro Arias Vasquez, Miguel E Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J Wright, Nicholas G Martin, Ingrid Agartz, Martin Alda, Saud Alhusaini, Laura Almasy, Jorge Almeida, Kathryn Alpert, Nancy C Andreasen, Ole A AndreassenLiana G Apostolova, Katja Appel, Nicola J Armstrong, Benjamin Aribisala, Mark E Bastin, Michael Bauer, Carrie E Bearden, Orjan Bergmann, Elisabeth B Binder, John Blangero, Henry J Bockholt, Erlend Bøen, Catherine Bois, Dorret I Boomsma, Patricia Conrod, Giuseppe Delvecchio, Danai Dima, Rali Dimitrova, Sophia Frangou, Eva Loth, Anbarasu Lourdusamy, Colm McDonald, Mary Phillips, Adaikalavan Ramasamy, Cathy Scanlon, Andrew Simmons, Robert Walker, Michael E Weale, Peter R Schofield, Natalia S Lawrence, the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group

Imaging Genetics Center, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90033, USA, [email protected].

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Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Original language	English
Article number	N/A
Pages (from-to)	N/A
Number of pages	30
Journal	Brain Imaging and Behavior
Volume	N/A
Issue number	N/A
DOIs	https://doi.org/10.1007/s11682-013-9269-5
Publication status	E-pub ahead of print - 8 Jan 2014

Keywords

Acknowledged-BRC
Acknowledged-BRC-13/14

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10.1007/s11682-013-9269-5

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Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M. J., Martin, N. G., Agartz, I., Alda, M., Alhusaini, S., Almasy, L., Almeida, J., Alpert, K., Andreasen, N. C., ... the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group (2014). The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, N/A(N/A), N/A. Article N/A. Advance online publication. https://doi.org/10.1007/s11682-013-9269-5

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title = "The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data",

abstract = "The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.",

keywords = "Acknowledged-BRC, Acknowledged-BRC-13/14",

author = "Thompson, {Paul M} and Stein, {Jason L} and Medland, {Sarah E} and Hibar, {Derrek P} and Vasquez, {Alejandro Arias} and Renteria, {Miguel E} and Roberto Toro and Neda Jahanshad and Gunter Schumann and Barbara Franke and Wright, {Margaret J} and Martin, {Nicholas G} and Ingrid Agartz and Martin Alda and Saud Alhusaini and Laura Almasy and Jorge Almeida and Kathryn Alpert and Andreasen, {Nancy C} and Andreassen, {Ole A} and Apostolova, {Liana G} and Katja Appel and Armstrong, {Nicola J} and Benjamin Aribisala and Bastin, {Mark E} and Michael Bauer and Bearden, {Carrie E} and Orjan Bergmann and Binder, {Elisabeth B} and John Blangero and Bockholt, {Henry J} and Erlend B{\o}en and Catherine Bois and Boomsma, {Dorret I} and Patricia Conrod and Giuseppe Delvecchio and Danai Dima and Rali Dimitrova and Sophia Frangou and Eva Loth and Anbarasu Lourdusamy and Colm McDonald and Mary Phillips and Adaikalavan Ramasamy and Cathy Scanlon and Andrew Simmons and Robert Walker and Weale, {Michael E} and Schofield, {Peter R} and Lawrence, {Natalia S} and {the Alzheimer{\textquoteright}s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group}",

year = "2014",

month = jan,

day = "8",

doi = "10.1007/s11682-013-9269-5",

language = "English",

volume = "N/A",

pages = "N/A",

journal = "Brain Imaging and Behavior",

issn = "1931-7565",

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Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Vasquez, AA, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Alda, M, Alhusaini, S, Almasy, L, Almeida, J, Alpert, K, Andreasen, NC, Andreassen, OA, Apostolova, LG, Appel, K, Armstrong, NJ, Aribisala, B, Bastin, ME, Bauer, M, Bearden, CE, Bergmann, O, Binder, EB, Blangero, J, Bockholt, HJ, Bøen, E, Bois, C, Boomsma, DI, Conrod, P , Delvecchio, G , Dima, D , Dimitrova, R , Frangou, S , Loth, E , Lourdusamy, A , McDonald, C , Phillips, M, Ramasamy, A, Scanlon, C , Simmons, A , Walker, R , Weale, ME, Schofield, PR, Lawrence, NS & the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group 2014, 'The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data', Brain Imaging and Behavior, vol. N/A, no. N/A, N/A, pp. N/A. https://doi.org/10.1007/s11682-013-9269-5

TY - JOUR

T1 - The ENIGMA Consortium

T2 - large-scale collaborative analyses of neuroimaging and genetic data

AU - Thompson, Paul M

AU - Stein, Jason L

AU - Medland, Sarah E

AU - Hibar, Derrek P

AU - Vasquez, Alejandro Arias

AU - Renteria, Miguel E

AU - Toro, Roberto

AU - Jahanshad, Neda

AU - Schumann, Gunter

AU - Franke, Barbara

AU - Wright, Margaret J

AU - Martin, Nicholas G

AU - Agartz, Ingrid

AU - Alda, Martin

AU - Alhusaini, Saud

AU - Almasy, Laura

AU - Almeida, Jorge

AU - Alpert, Kathryn

AU - Andreasen, Nancy C

AU - Andreassen, Ole A

AU - Apostolova, Liana G

AU - Appel, Katja

AU - Armstrong, Nicola J

AU - Aribisala, Benjamin

AU - Bastin, Mark E

AU - Bauer, Michael

AU - Bearden, Carrie E

AU - Bergmann, Orjan

AU - Binder, Elisabeth B

AU - Blangero, John

AU - Bockholt, Henry J

AU - Bøen, Erlend

AU - Bois, Catherine

AU - Boomsma, Dorret I

AU - Conrod, Patricia

AU - Delvecchio, Giuseppe

AU - Dima, Danai

AU - Dimitrova, Rali

AU - Frangou, Sophia

AU - Loth, Eva

AU - Lourdusamy, Anbarasu

AU - McDonald, Colm

AU - Phillips, Mary

AU - Ramasamy, Adaikalavan

AU - Scanlon, Cathy

AU - Simmons, Andrew

AU - Walker, Robert

AU - Weale, Michael E

AU - Schofield, Peter R

AU - Lawrence, Natalia S

AU - the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group

PY - 2014/1/8

Y1 - 2014/1/8

N2 - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

AB - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

KW - Acknowledged-BRC

KW - Acknowledged-BRC-13/14

U2 - 10.1007/s11682-013-9269-5

DO - 10.1007/s11682-013-9269-5

M3 - Article

C2 - 24399358

SN - 1931-7565

VL - N/A

SP - N/A

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - N/A

M1 - N/A

ER -

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Abstract

Keywords

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