The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Nader Joghetaei; Andreas Stein; Robert A. Byrne; Christian Schulz; Lamin King; Andreas E. May; Roland Schmidt

doi:10.1016/j.thromres.2013.04.017

The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Nader Joghetaei, Andreas Stein, Robert A. Byrne, Christian Schulz, Lamin King, Andreas E. May, Roland Schmidt^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Literature review › peer-review

22 Citations (Scopus)

Abstract

The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN- associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation. (C) 2013 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	474-480
Number of pages	7
Journal	Thrombosis Research
Volume	131
Issue number	6
DOIs	https://doi.org/10.1016/j.thromres.2013.04.017
Publication status	Published - Jun 2013

Keywords

Atherogenesis
Atherothrombosis
EMMPRIN
LOW-DENSITY LIPOPROTEINS
SMOOTH-MUSCLE-CELLS
IMMUNOGLOBULIN SUPERFAMILY
FOAM CELLS
MYOCARDIAL-INFARCTION
MONOCLONAL-ANTIBODIES
LIGAND CYCLOPHILIN
EXPRESSION
ATHEROSCLEROSIS
COLLAGENASE

Access to Document

10.1016/j.thromres.2013.04.017

Cite this

@article{03e46d26f0724e0e9c754e354b603225,

title = "The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?",

abstract = "The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN- associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation. (C) 2013 Elsevier Ltd. All rights reserved.",

keywords = "Atherogenesis, Atherothrombosis, EMMPRIN, LOW-DENSITY LIPOPROTEINS, SMOOTH-MUSCLE-CELLS, IMMUNOGLOBULIN SUPERFAMILY, FOAM CELLS, MYOCARDIAL-INFARCTION, MONOCLONAL-ANTIBODIES, LIGAND CYCLOPHILIN, EXPRESSION, ATHEROSCLEROSIS, COLLAGENASE",

author = "Nader Joghetaei and Andreas Stein and Byrne, {Robert A.} and Christian Schulz and Lamin King and May, {Andreas E.} and Roland Schmidt",

year = "2013",

month = jun,

doi = "10.1016/j.thromres.2013.04.017",

language = "English",

volume = "131",

pages = "474--480",

journal = "Thrombosis Research",

issn = "0049-3848",