@article{9fe10fc76a3a403eaae586f889871f25,
title = "The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project",
abstract = "Abstract Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection. We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site. Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia.",
keywords = "Schizophrenia, Neuropsychology, Cognition, Neuroimaging, MRI, Genetics",
author = "Blokland, {Gabri{\"e}lla A.M.} and {del Re}, {Elisabetta C.} and Mesholam-Gately, {Raquelle I.} and Jorge Jovicich and Trampush, {Joey W.} and Keshavan, {Matcheri S.} and DeLisi, {Lynn E.} and Walters, {James T.R.} and Turner, {Jessica A.} and Malhotra, {Anil K.} and Todd Lencz and Shenton, {Martha E.} and Voineskos, {Aristotle N.} and Dan Rujescu and Ina Giegling and Kahn, {Ren{\'e} S.} and Roffman, {Joshua L.} and Holt, {Daphne J.} and Stefan Ehrlich and Zora Kikinis and Paola Dazzan and Murray, {Robin M.} and {Di Forti}, Marta and Jimmy Lee and Kang Sim and Max Lam and Wolthusen, {Rick P.F.} and {de Zwarte}, {Sonja M.C.} and Esther Walton and Donna Cosgrove and Sinead Kelly and Nasim Maleki and Lisa Osiecki and Picchioni, {Marco M.} and Elvira Bramon and Manuela Russo and David, {Anthony S.} and Valeria Mondelli and Reinders, {Antje A.T.S.} and Falcone, {M. Aurora} and Hartmann, {Annette M.} and Bettina Konte and Morris, {Derek W.} and Michael Gill and Corvin, {Aiden P.} and Wiepke Cahn and Ho, {New Fei} and Liu, {Jian Jun} and Keefe, {Richard S.E.} and Gollub, {Randy L.} and Manoach, {Dara S.} and Calhoun, {Vince D.} and Schulz, {S. Charles} and Sponheim, {Scott R.} and Goff, {Donald C.} and Buka, {Stephen L.} and Sara Cherkerzian and Thermenos, {Heidi W.} and Marek Kubicki and Nestor, {Paul G.} and Dickie, {Erin W.} and Evangelos Vassos and Simone Ciufolini and {Reis Marques}, Tiago and Crossley, {Nicolas A.} and Purcell, {Shaun M.} and Smoller, {Jordan W.} and {van Haren}, {Neeltje E.M.} and Timothea Toulopoulou and Gary Donohoe and Goldstein, {Jill M.} and Seidman, {Larry J.} and McCarley, {Robert W.} and Petryshen, {Tracey L.}",
year = "2017",
month = oct,
day = "3",
doi = "10.1016/j.schres.2017.09.024",
language = "English",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
}