The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans

Akila De Silva; Victoria Salem; Christopher J Long; Aidan Makwana; Rexford D Newbould; Eugenii Rabiner; Mohammad A Ghatei; Stephen R Bloom; Paul M Matthews; John D Beaver; Waljit S Dhillo

doi:10.1016/j.cmet.2011.09.010

The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans

Akila De Silva, Victoria Salem, Christopher J Long, Aidan Makwana, Rexford D Newbould, Eugenii Rabiner, Mohammad A Ghatei, Stephen R Bloom, Paul M Matthews, John D Beaver, Waljit S Dhillo

NIHR Maudsley Biomedical Research Centre (BRC)

Research output: Contribution to journal › Article › peer-review

272 Citations (Scopus)

Abstract

Obesity is a major public health issue worldwide. Understanding how the brain controls appetite offers promising inroads toward new therapies for obesity. Peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) are coreleased postprandially and reduce appetite and inhibit food intake when administered to humans. However, the effects of GLP-1 and the ways in which PYY and GLP-1 act together to modulate brain activity in humans are unknown. Here, we have used functional MRI to determine these effects in healthy, normal-weight human subjects and compared them to those seen physiologically following a meal. We provide a demonstration that the combined administration of PYY(3-36) and GLP-1(7-36 amide) to fasted human subjects leads to similar reductions in subsequent energy intake and brain activity, as observed physiologically following feeding.

Original language	English
Pages (from-to)	700-706
Number of pages	7
Journal	CELL METABOLISM
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2011.09.010
Publication status	Published - 2011

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10.1016/j.cmet.2011.09.010

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title = "The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans",

abstract = "Obesity is a major public health issue worldwide. Understanding how the brain controls appetite offers promising inroads toward new therapies for obesity. Peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) are coreleased postprandially and reduce appetite and inhibit food intake when administered to humans. However, the effects of GLP-1 and the ways in which PYY and GLP-1 act together to modulate brain activity in humans are unknown. Here, we have used functional MRI to determine these effects in healthy, normal-weight human subjects and compared them to those seen physiologically following a meal. We provide a demonstration that the combined administration of PYY(3-36) and GLP-1(7-36 amide) to fasted human subjects leads to similar reductions in subsequent energy intake and brain activity, as observed physiologically following feeding.",

author = "{De Silva}, Akila and Victoria Salem and Long, {Christopher J} and Aidan Makwana and Newbould, {Rexford D} and Eugenii Rabiner and Ghatei, {Mohammad A} and Bloom, {Stephen R} and Matthews, {Paul M} and Beaver, {John D} and Dhillo, {Waljit S}",

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AU - De Silva, Akila

AU - Salem, Victoria

AU - Long, Christopher J

AU - Makwana, Aidan

AU - Newbould, Rexford D

AU - Rabiner, Eugenii

AU - Ghatei, Mohammad A

AU - Bloom, Stephen R

AU - Matthews, Paul M

AU - Beaver, John D

AU - Dhillo, Waljit S

PY - 2011

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AB - Obesity is a major public health issue worldwide. Understanding how the brain controls appetite offers promising inroads toward new therapies for obesity. Peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) are coreleased postprandially and reduce appetite and inhibit food intake when administered to humans. However, the effects of GLP-1 and the ways in which PYY and GLP-1 act together to modulate brain activity in humans are unknown. Here, we have used functional MRI to determine these effects in healthy, normal-weight human subjects and compared them to those seen physiologically following a meal. We provide a demonstration that the combined administration of PYY(3-36) and GLP-1(7-36 amide) to fasted human subjects leads to similar reductions in subsequent energy intake and brain activity, as observed physiologically following feeding.

U2 - 10.1016/j.cmet.2011.09.010

DO - 10.1016/j.cmet.2011.09.010

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JF - CELL METABOLISM

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ER -

The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans

Abstract

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