@article{ffe90d126b964c2abd8b5e5572dbe014,
title = "The Hantzsch reaction for nitrogen-13 PET: preparation of [13N]nifedipine and derivatives",
abstract = "Nitrogen-13 is an attractive but under-used PET radionuclide for labelling molecules of biological and pharmaceutical interest, complementing other PET radionuclides. Its short half-life (t1/2 = 9.97 min) imposes synthetic challenges, but we have expanded the hitherto limited pool of 13N labelling strategies and tracers by adapting the multicomponent Hantzsch condensation reaction to prepare a library of 13N-labelled 1,4-dihydropyridines from [13N]ammonia, including the widely-used drug nifedipine. This represents a key advance in 13N PET radiochemistry, and will serve to underpin the renewed interest in clinical opportunities offered by short-lived PET tracers.",
author = "Julia Blower and Michelle Ma and Fahad Al-Salemee and Tony Gee",
note = "Funding Information: The authors would like to thank Dr JB Torres and Mr S Clarke for their assistance with preclinical imaging. This research was supported by the PET Centre at St Thomas{\textquoteright} Hospital and the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy{\textquoteright}s & St Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London and King{\textquoteright}s College Hospital NHS Foundation Trust; a Cancer Research UK Career Establishment Award [C63178/A24959]; the Wellcome Trust funded {\textquoteleft}Multi-User radioanalytical facility for molecular imaging and radionuclide therapy research{\textquoteright} [212885/Z/18/Z]; Wellcome/EPSRC Centre for Medical Engineering at King{\textquoteright}s College London [WT 203148/Z/16/Z]; the EPSRC programme for next generation molecular imaging and therapy with radionuclides [EP/S019901/1]. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the DoH. Publisher Copyright: {\textcopyright} 2021 The Royal Society of Chemistry. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "18",
doi = "10.1039/d1cc00495f",
language = "English",
volume = "57",
pages = "4962--4965",
journal = "Chemical communications (Cambridge, England)",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "40",
}