The on-off story of protein palmitoylation

M J Bijlmakers; M Marsh

doi:10.1016/S0962-8924(02)00008-9

The on-off story of protein palmitoylation

M J Bijlmakers, M Marsh

Research output: Contribution to journal › Literature review › peer-review

269 Citations (Scopus)

Abstract

Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.

Original language	English
Pages (from-to)	32 - 42
Number of pages	11
Journal	TRENDS IN CELL BIOLOGY
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/S0962-8924(02)00008-9
Publication status	Published - 1 Jan 2003

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AB - Palmitoylation is one of the most frequent post-translational modifications found on proteins. It contributes to membrane association, protein sorting and many other processes. Through its reversibility, palmitoylation also provides mechanisms to regulate the functional activities of integral and peripheral membrane proteins. Here we discuss evidence that proteins can be palmitoylated at different locations in the cell, how targeting to these locations might be directed, and aspects of the proposed functions of palmitoylation.

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DO - 10.1016/S0962-8924(02)00008-9

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JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

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The on-off story of protein palmitoylation

Abstract

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