The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

R N Gogoi; F R Schubert; J P Martinez-Barbera; D Acampora; A Simeone; A Lumsden

doi:10.1016/S0925-4773(02)00067-9

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

R N Gogoi, F R Schubert, J P Martinez-Barbera, D Acampora, A Simeone, A Lumsden

King's College London

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	213 - 217
Number of pages	5
Journal	Mechanisms of Development
Volume	114
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(02)00067-9
Publication status	Published - 2002

Access to Document

10.1016/S0925-4773(02)00067-9

Cite this

@article{2ad4fdae8c9c4500b1eff6389bc8b781,

title = "The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum",

abstract = "We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.",

author = "Gogoi, {R N} and Schubert, {F R} and Martinez-Barbera, {J P} and D Acampora and A Simeone and A Lumsden",

year = "2002",

doi = "10.1016/S0925-4773(02)00067-9",

language = "English",

volume = "114",

pages = "213 -- 217",

journal = "Mechanisms of Development",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

AU - Gogoi, R N

AU - Schubert, F R

AU - Martinez-Barbera, J P

AU - Acampora, D

AU - Simeone, A

AU - Lumsden, A

PY - 2002

Y1 - 2002

N2 - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

AB - We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=0036011269&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(02)00067-9

DO - 10.1016/S0925-4773(02)00067-9

M3 - Article

VL - 114

SP - 213

EP - 217

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

Abstract

Access to Document

Other files and links

Fingerprint

Cite this