The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

Khadija Alawi; Julie Keeble

doi:10.1016/j.pharmthera.2009.10.005

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

Khadija Alawi, Julie Keeble

Institute of Pharmaceutical Science

King's College London

Research output: Contribution to journal › Literature review › peer-review

153 Citations (Scopus)

Abstract

The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers. In addition, endogenous compounds, in particular the endogenous cannabinoid receptor activator, anandamide, have been demonstrated to activate TRPV1 in vivo. TRPV1 receptors are also activated by temperatures within the noxious range (>43 degrees C) and low pH (

Original language	English
Pages (from-to)	181 - 195
Number of pages	15
Journal	Pharmacology and Therapeutics
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.pharmthera.2009.10.005
Publication status	Published - Feb 2010

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10.1016/j.pharmthera.2009.10.005

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title = "The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation",

abstract = "The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers. In addition, endogenous compounds, in particular the endogenous cannabinoid receptor activator, anandamide, have been demonstrated to activate TRPV1 in vivo. TRPV1 receptors are also activated by temperatures within the noxious range (>43 degrees C) and low pH (",

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AB - The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers. In addition, endogenous compounds, in particular the endogenous cannabinoid receptor activator, anandamide, have been demonstrated to activate TRPV1 in vivo. TRPV1 receptors are also activated by temperatures within the noxious range (>43 degrees C) and low pH (

U2 - 10.1016/j.pharmthera.2009.10.005

DO - 10.1016/j.pharmthera.2009.10.005

M3 - Literature review

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SP - 181

EP - 195

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 2

ER -

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

Abstract

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