The receptor tyrosine kinase FIt3 is required for dendritic cell development in peripheral lymphoid tissues

Claudia Waskow; Kang Liu; Guillaume Darrasse-Jeze; Pierre Guermonprez; Florent Ginhoux; Miriam Merad; Tamara Shengelia; Kaihui Yao; Michel Nussenzweig

doi:10.1038/ni.1615

The receptor tyrosine kinase FIt3 is required for dendritic cell development in peripheral lymphoid tissues

Claudia Waskow, Kang Liu, Guillaume Darrasse-Jeze, Pierre Guermonprez, Florent Ginhoux, Miriam Merad, Tamara Shengelia, Kaihui Yao, Michel Nussenzweig

Inflammation Biology

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504 Citations (Scopus)

Abstract

Dendritic cell (DC) development begins in the bone marrow but is not completed until after immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic growth factors regulating these processes are poorly understood. Here we examined the effects of signaling by the receptor tyrosine kinase Flt3 on macrophage DC progenitors in the bone marrow and on peripheral DCs. We found that the macrophage DC progenitor compartment was responsive to superphysiological amounts of Flt3 ligand but was not dependent on Flt3 for its homeostatic maintenance in vivo. In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery.

Original language	English
Pages (from-to)	676 - 683
Number of pages	8
Journal	Nature Immunology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/ni.1615
Publication status	Published - Jun 2008

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title = "The receptor tyrosine kinase FIt3 is required for dendritic cell development in peripheral lymphoid tissues",

abstract = "Dendritic cell (DC) development begins in the bone marrow but is not completed until after immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic growth factors regulating these processes are poorly understood. Here we examined the effects of signaling by the receptor tyrosine kinase Flt3 on macrophage DC progenitors in the bone marrow and on peripheral DCs. We found that the macrophage DC progenitor compartment was responsive to superphysiological amounts of Flt3 ligand but was not dependent on Flt3 for its homeostatic maintenance in vivo. In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery.",

author = "Claudia Waskow and Kang Liu and Guillaume Darrasse-Jeze and Pierre Guermonprez and Florent Ginhoux and Miriam Merad and Tamara Shengelia and Kaihui Yao and Michel Nussenzweig",

year = "2008",

month = jun,

doi = "10.1038/ni.1615",

language = "English",

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journal = "Nature Immunology",

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T1 - The receptor tyrosine kinase FIt3 is required for dendritic cell development in peripheral lymphoid tissues

AU - Waskow, Claudia

AU - Liu, Kang

AU - Darrasse-Jeze, Guillaume

AU - Guermonprez, Pierre

AU - Ginhoux, Florent

AU - Merad, Miriam

AU - Shengelia, Tamara

AU - Yao, Kaihui

AU - Nussenzweig, Michel

PY - 2008/6

Y1 - 2008/6

N2 - Dendritic cell (DC) development begins in the bone marrow but is not completed until after immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic growth factors regulating these processes are poorly understood. Here we examined the effects of signaling by the receptor tyrosine kinase Flt3 on macrophage DC progenitors in the bone marrow and on peripheral DCs. We found that the macrophage DC progenitor compartment was responsive to superphysiological amounts of Flt3 ligand but was not dependent on Flt3 for its homeostatic maintenance in vivo. In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery.

AB - Dendritic cell (DC) development begins in the bone marrow but is not completed until after immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic growth factors regulating these processes are poorly understood. Here we examined the effects of signaling by the receptor tyrosine kinase Flt3 on macrophage DC progenitors in the bone marrow and on peripheral DCs. We found that the macrophage DC progenitor compartment was responsive to superphysiological amounts of Flt3 ligand but was not dependent on Flt3 for its homeostatic maintenance in vivo. In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery.

U2 - 10.1038/ni.1615

DO - 10.1038/ni.1615

M3 - Article

VL - 9

SP - 676

EP - 683

JO - Nature Immunology

JF - Nature Immunology

IS - 6

ER -

The receptor tyrosine kinase FIt3 is required for dendritic cell development in peripheral lymphoid tissues

Abstract

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