TY - JOUR
T1 - The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (COPD)
AU - Garrod, Rachel
AU - Marshall, Johanna
AU - Barley, Elizabeth
AU - Fredericks, Salim
AU - Hagan, Gerry
PY - 2007/8
Y1 - 2007/8
N2 - AIMS: To examine relationships between markers of systemic inflammation and functional status in patients with chronic obstructive pulmonary disease (COPD). METHODS: 41 COPD patients were stratified using the Medical Research Council (MRC) dyspnoea scale. Six-minute walking distance (6MWD), Quadriceps (% body weight) (QBW), St George’s Hospital Respiratory Questionnaire (SGRQ), London Chest Activity of Daily Living Scale (LCADL), C-reactive protein (CRP), interleukin 6 (IL6), tumour necrosis factor α, and neopterin were measured. Relationships between variables and differences in inflammatory markers between MRC categories were tested. RESULTS: Inflammation increased with MRC grade and was significantly different across grades; CRP (p=0.002) and IL6 (p=0.04). Relationships were evident between CRP, 6MWD, LCADL and SGRQ, r=-0.47, 0.50, 0.43 (all p<0.01) respectively, and between IL6, QBW and LCADL, rho=-0.36, 0.51 (p<0.05). CONCLUSIONS: Measures of systemic inflammation, and in particular CRP, may prove to be useful markers in the assessment of COPD severity in primary care.
AB - AIMS: To examine relationships between markers of systemic inflammation and functional status in patients with chronic obstructive pulmonary disease (COPD). METHODS: 41 COPD patients were stratified using the Medical Research Council (MRC) dyspnoea scale. Six-minute walking distance (6MWD), Quadriceps (% body weight) (QBW), St George’s Hospital Respiratory Questionnaire (SGRQ), London Chest Activity of Daily Living Scale (LCADL), C-reactive protein (CRP), interleukin 6 (IL6), tumour necrosis factor α, and neopterin were measured. Relationships between variables and differences in inflammatory markers between MRC categories were tested. RESULTS: Inflammation increased with MRC grade and was significantly different across grades; CRP (p=0.002) and IL6 (p=0.04). Relationships were evident between CRP, 6MWD, LCADL and SGRQ, r=-0.47, 0.50, 0.43 (all p<0.01) respectively, and between IL6, QBW and LCADL, rho=-0.36, 0.51 (p<0.05). CONCLUSIONS: Measures of systemic inflammation, and in particular CRP, may prove to be useful markers in the assessment of COPD severity in primary care.
U2 - 10.3132/pcrj.2007.00047
DO - 10.3132/pcrj.2007.00047
M3 - Article
C2 - 17665081
SN - 1471-4418
VL - 16
SP - 236
EP - 240
JO - Primary Care Respiratory Journal
JF - Primary Care Respiratory Journal
IS - 4
ER -