The role of diabetes and other co-morbidities on survival after esophageal cancer surgery in a population-based study

Lovisa Backemar; Therese Djarv; Anna Wikman; Asif Johar; Paul Ross; Pernilla Lagergren; Jesper Lagergren

doi:10.1016/j.amjsurg.2013.01.035

The role of diabetes and other co-morbidities on survival after esophageal cancer surgery in a population-based study

Lovisa Backemar^*, Therese Djarv, Anna Wikman, Asif Johar, Paul Ross, Pernilla Lagergren, Jesper Lagergren

^*Corresponding author for this work

Karolinska Institute

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

BACKGROUND: There is limited knowledge on how diabetes and other comorbidities influence the survival of patients undergoing curative esophageal cancer surgery.

METHODS: A population-based and prospective cohort study included patients who underwent surgical resection for esophageal or cardia cancer in Sweden from 2001 to 2005, with follow-up until 2011. Associations between diabetes and other comorbidities in relation to postoperative mortality were analyzed using Cox proportional-hazards regression with adjustment for potential confounding factors.

RESULTS: Among 609 patients, 67 (11%) with diabetes had no increased risk for mortality compared with those without diabetes (hazard ratio,.81; 95% confidence interval, .60 to 1.09). Compared with patients without any predefined comorbidities, those with 1 (hazard ratio, 1.15; 95% confidence interval, .93 to 1.43) or >= 2 comorbidities (hazard ratio, 1.05; 95% confidence interval, .83 to 1.33) had no statistically significantly increased risk for mortality.

CONCLUSIONS: This study revealed no strongly increased risk for mortality in patients with diabetes or other comorbidities selected for esophageal cancer surgery.

Original language	English
Pages (from-to)	539-543
Number of pages	5
Journal	American Journal of Surgery
Volume	206
Issue number	4
DOIs	https://doi.org/10.1016/j.amjsurg.2013.01.035
Publication status	Published - Oct 2013

Keywords

Prospective
Esophagectomy
Esophageal resection
Postoperative
Cardia
COLORECTAL-CANCER
RESECTION
MELLITUS
OUTCOMES
RISK
COMPLICATIONS
CARCINOMA
SWEDEN
IMPACT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjsurg.2013.01.035

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title = "The role of diabetes and other co-morbidities on survival after esophageal cancer surgery in a population-based study",

abstract = "BACKGROUND: There is limited knowledge on how diabetes and other comorbidities influence the survival of patients undergoing curative esophageal cancer surgery. METHODS: A population-based and prospective cohort study included patients who underwent surgical resection for esophageal or cardia cancer in Sweden from 2001 to 2005, with follow-up until 2011. Associations between diabetes and other comorbidities in relation to postoperative mortality were analyzed using Cox proportional-hazards regression with adjustment for potential confounding factors. RESULTS: Among 609 patients, 67 (11%) with diabetes had no increased risk for mortality compared with those without diabetes (hazard ratio,.81; 95% confidence interval, .60 to 1.09). Compared with patients without any predefined comorbidities, those with 1 (hazard ratio, 1.15; 95% confidence interval, .93 to 1.43) or >= 2 comorbidities (hazard ratio, 1.05; 95% confidence interval, .83 to 1.33) had no statistically significantly increased risk for mortality. CONCLUSIONS: This study revealed no strongly increased risk for mortality in patients with diabetes or other comorbidities selected for esophageal cancer surgery.",

keywords = "Prospective, Esophagectomy, Esophageal resection, Postoperative, Cardia, COLORECTAL-CANCER, RESECTION, MELLITUS, OUTCOMES, RISK, COMPLICATIONS, CARCINOMA, SWEDEN, IMPACT",

author = "Lovisa Backemar and Therese Djarv and Anna Wikman and Asif Johar and Paul Ross and Pernilla Lagergren and Jesper Lagergren",

year = "2013",

month = oct,

doi = "10.1016/j.amjsurg.2013.01.035",

language = "English",

volume = "206",

pages = "539--543",

journal = "American Journal of Surgery",

issn = "0002-9610",

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TY - JOUR

T1 - The role of diabetes and other co-morbidities on survival after esophageal cancer surgery in a population-based study

AU - Backemar, Lovisa

AU - Djarv, Therese

AU - Wikman, Anna

AU - Johar, Asif

AU - Ross, Paul

AU - Lagergren, Pernilla

AU - Lagergren, Jesper

PY - 2013/10

Y1 - 2013/10

N2 - BACKGROUND: There is limited knowledge on how diabetes and other comorbidities influence the survival of patients undergoing curative esophageal cancer surgery. METHODS: A population-based and prospective cohort study included patients who underwent surgical resection for esophageal or cardia cancer in Sweden from 2001 to 2005, with follow-up until 2011. Associations between diabetes and other comorbidities in relation to postoperative mortality were analyzed using Cox proportional-hazards regression with adjustment for potential confounding factors. RESULTS: Among 609 patients, 67 (11%) with diabetes had no increased risk for mortality compared with those without diabetes (hazard ratio,.81; 95% confidence interval, .60 to 1.09). Compared with patients without any predefined comorbidities, those with 1 (hazard ratio, 1.15; 95% confidence interval, .93 to 1.43) or >= 2 comorbidities (hazard ratio, 1.05; 95% confidence interval, .83 to 1.33) had no statistically significantly increased risk for mortality. CONCLUSIONS: This study revealed no strongly increased risk for mortality in patients with diabetes or other comorbidities selected for esophageal cancer surgery.

AB - BACKGROUND: There is limited knowledge on how diabetes and other comorbidities influence the survival of patients undergoing curative esophageal cancer surgery. METHODS: A population-based and prospective cohort study included patients who underwent surgical resection for esophageal or cardia cancer in Sweden from 2001 to 2005, with follow-up until 2011. Associations between diabetes and other comorbidities in relation to postoperative mortality were analyzed using Cox proportional-hazards regression with adjustment for potential confounding factors. RESULTS: Among 609 patients, 67 (11%) with diabetes had no increased risk for mortality compared with those without diabetes (hazard ratio,.81; 95% confidence interval, .60 to 1.09). Compared with patients without any predefined comorbidities, those with 1 (hazard ratio, 1.15; 95% confidence interval, .93 to 1.43) or >= 2 comorbidities (hazard ratio, 1.05; 95% confidence interval, .83 to 1.33) had no statistically significantly increased risk for mortality. CONCLUSIONS: This study revealed no strongly increased risk for mortality in patients with diabetes or other comorbidities selected for esophageal cancer surgery.

KW - Prospective

KW - Esophagectomy

KW - Esophageal resection

KW - Postoperative

KW - Cardia

KW - COLORECTAL-CANCER

KW - RESECTION

KW - MELLITUS

KW - OUTCOMES

KW - RISK

KW - COMPLICATIONS

KW - CARCINOMA

KW - SWEDEN

KW - IMPACT

U2 - 10.1016/j.amjsurg.2013.01.035

DO - 10.1016/j.amjsurg.2013.01.035

M3 - Article

SN - 0002-9610

VL - 206

SP - 539

EP - 543

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 4

ER -

The role of diabetes and other co-morbidities on survival after esophageal cancer surgery in a population-based study

Abstract

Keywords

UN SDGs

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