TY - JOUR
T1 - The role of intestinal microbiota on pre-eclampsia
T2 - Systematic review and meta-analysis
AU - Colonetti, Tamy
AU - Limas Carmo Teixeira, Diandra
AU - Grande, Antonio José
AU - Rodrigues Uggioni, Maria Laura
AU - Generoso, Jaqueline
AU - Harding, Seeromanie
AU - Rodriguez-Mateos, Ana
AU - Rech, Peterson
AU - Rosa Silva, Fabio
AU - Toreti, Indianara
AU - Ceretta, Luciane
AU - Rosa, Maria Inês
N1 - Copyright © 2023 Elsevier B.V. All rights reserved.
PY - 2023/12
Y1 - 2023/12
N2 - AIM: To investigate differences between gut microbiota diversity and composition of healthy pregnant women and women with pre-eclampsia (PE).METHODS AND RESULTS: This is a systematic review and meta-analysis of the literature, in which the terms "pre-eclampsia", "gastrointestinal microbiome" and "pregnant women" were used to search MEDLINE (PubMed), BVS (LILACS and others), Embase (Elsevier) and Cochrane Library, including observational studies and case-control that investigated changes in the gut microbiota during pregnancy. Six studies were included, with 479 pregnant women. A significantly lower gut microbiota alpha diversity measured as the Shannon index was found in pregnant women with PE in comparison with healthy controls (SMD: -0.47; 95 %IC: -0.77 to -0.18; P = 0.02; I2 = 0 %; three studies, 179 participants), while no significant differences were found in the relative abundance of Bacteroidetes, Firmicutes, Actinobacteria, and Proteobacteria, despite significant differences reported in the individual studies.CONCLUSION: Pregnant women with PE have lower gut microbiome diversity, however, there is insufficient evidence to determine whether there are changes in gut microbiota composition.SIGNIFICANCE AND IMPACT OF THE STUDY: The gut microbiota can be a new treatment target to try to prevent changes in maternal bacterial proportions, aiming to reduce complications during pregnancy.
AB - AIM: To investigate differences between gut microbiota diversity and composition of healthy pregnant women and women with pre-eclampsia (PE).METHODS AND RESULTS: This is a systematic review and meta-analysis of the literature, in which the terms "pre-eclampsia", "gastrointestinal microbiome" and "pregnant women" were used to search MEDLINE (PubMed), BVS (LILACS and others), Embase (Elsevier) and Cochrane Library, including observational studies and case-control that investigated changes in the gut microbiota during pregnancy. Six studies were included, with 479 pregnant women. A significantly lower gut microbiota alpha diversity measured as the Shannon index was found in pregnant women with PE in comparison with healthy controls (SMD: -0.47; 95 %IC: -0.77 to -0.18; P = 0.02; I2 = 0 %; three studies, 179 participants), while no significant differences were found in the relative abundance of Bacteroidetes, Firmicutes, Actinobacteria, and Proteobacteria, despite significant differences reported in the individual studies.CONCLUSION: Pregnant women with PE have lower gut microbiome diversity, however, there is insufficient evidence to determine whether there are changes in gut microbiota composition.SIGNIFICANCE AND IMPACT OF THE STUDY: The gut microbiota can be a new treatment target to try to prevent changes in maternal bacterial proportions, aiming to reduce complications during pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=85173954316&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2023.10.003
DO - 10.1016/j.ejogrb.2023.10.003
M3 - Review article
C2 - 37826991
SN - 0301-2115
VL - 291
SP - 49
EP - 58
JO - European Journal of Obstetrics Gynecology and Reproductive Biology
JF - European Journal of Obstetrics Gynecology and Reproductive Biology
ER -