TY - JOUR
T1 - The role of physical activity in nonalcoholic and metabolic dysfunction associated fatty liver disease
AU - von Loeffelholz, Christian
AU - Roth, Johannes
AU - Coldewey, Sina M.
AU - Birkenfeld, Andreas L.
N1 - Funding Information:
Acknowledgments: We thankfully acknowledge financial support by DFG-funded Collaborative Research Center/Transregio 124 FungiNet (Project C5 to CvL) and by the Federal Ministry of Education and Research within the Centre for Innovation Competence Septomics (Translational Septomics, grant 03Z22JN12 to SMC).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12
Y1 - 2021/12
N2 - Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and par-ticularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, predia-betes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients’ motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.
AB - Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and par-ticularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, predia-betes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients’ motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.
KW - AMP activated protein kinase
KW - Ectopic lipids
KW - Insulin resistance
KW - Nonexercise activity thermogenesis
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85121713474&partnerID=8YFLogxK
U2 - 10.3390/biomedicines9121853
DO - 10.3390/biomedicines9121853
M3 - Article
AN - SCOPUS:85121713474
VL - 9
JO - Biomedicines
JF - Biomedicines
IS - 12
M1 - 1853
ER -
