TY - JOUR
T1 - The role of TXNIP in cancer
T2 - a fine balance between redox, metabolic, and immunological tumor control
AU - Deng, Jinhai
AU - Pan, Teng
AU - Liu, Zaoqu
AU - McCarthy, Caitlin
AU - Vicencio, Jose M.
AU - Cao, Lulu
AU - Alfano, Giovanna
AU - Suwaidan, Ali Abdulnabi
AU - Yin, Mingzhu
AU - Beatson, Richard
AU - Ng, Tony
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12/7
Y1 - 2023/12/7
N2 - Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target.
AB - Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target.
UR - http://www.scopus.com/inward/record.url?scp=85173464572&partnerID=8YFLogxK
U2 - 10.1038/s41416-023-02442-4
DO - 10.1038/s41416-023-02442-4
M3 - Review article
C2 - 37794178
AN - SCOPUS:85173464572
SN - 0007-0920
VL - 129
SP - 1877
EP - 1892
JO - British journal of cancer
JF - British journal of cancer
IS - 12
ER -
