The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain

N J Bray; P R Buckland; H Hall; M J Owen; M C O'Donovan

doi:10.1038/sj.mp.4001366

The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain

N J Bray, P R Buckland, H Hall, M J Owen, M C O'Donovan

Research output: Contribution to journal › Article › peer-review

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Abstract

The serotonin-2A (HTR2A) receptor is a molecule of particular interest in biological psychiatry, as it is an important target for psychotropic drugs, and altered HTR2A expression has been found in several neuropsychiatric conditions, including depression and schizophrenia. Genetic association has been reported between a synonymous 102T/C polymorphism in the gene encoding HTR2A and a number of clinical phenotypes, including schizophrenia, clozapine response, psychotic symptoms in Alzheimer's disease and certain features of depression. Given that there are no known effects of the 102T/C polymorphism on the structure of the receptor, attention has switched to the possibility that the observations of both altered expression and genetic association point to functional sequence variants that alter expression of the HTR2A gene. Moreover, data have been presented recently suggesting that mRNAs containing the

Original language	English
Pages (from-to)	109 - 114
Number of pages	6
Journal	Molecular Psychiatry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/sj.mp.4001366
Publication status	Published - 2004

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abstract = "The serotonin-2A (HTR2A) receptor is a molecule of particular interest in biological psychiatry, as it is an important target for psychotropic drugs, and altered HTR2A expression has been found in several neuropsychiatric conditions, including depression and schizophrenia. Genetic association has been reported between a synonymous 102T/C polymorphism in the gene encoding HTR2A and a number of clinical phenotypes, including schizophrenia, clozapine response, psychotic symptoms in Alzheimer's disease and certain features of depression. Given that there are no known effects of the 102T/C polymorphism on the structure of the receptor, attention has switched to the possibility that the observations of both altered expression and genetic association point to functional sequence variants that alter expression of the HTR2A gene. Moreover, data have been presented recently suggesting that mRNAs containing the",

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AU - Owen, M J

AU - O'Donovan, M C

PY - 2004

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JF - Molecular Psychiatry

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The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain

Abstract

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