The serotonin transporter gene and peer-rated neuroticism

D Ball; L Hill; B Freeman; T C Eley; J Strelau; R Riemann; F M Spinath; A Angleitner; R Plomin

doi:10.1097/00001756-199703240-00048

The serotonin transporter gene and peer-rated neuroticism

D Ball, L Hill, B Freeman, T C Eley, J Strelau, R Riemann, F M Spinath, A Angleitner, R Plomin

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131 Citations (Scopus)

Abstract

Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires. We attempted to extend these findings using a selected extremes design and peer ratings. From a sample of 2085 individuals, each assessed on neuroticism by two independent peers, we selected 52 individuals from the top 5% and 54 individuals from the bottom 5%. No association was found for either a functional 44 bp insertion/deletion polymorphism in 5HTT regulatory sequence (5HTTLPR) or for a non-functional variable number tandem repeat 5HTT polymorphism.

Original language	English
Pages (from-to)	1301-4
Number of pages	4
Journal	Neuroreport
Volume	8
Issue number	5
DOIs	https://doi.org/10.1097/00001756-199703240-00048
Publication status	Published - 1997

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AU - Ball, D

AU - Hill, L

AU - Freeman, B

AU - Eley, T C

AU - Strelau, J

AU - Riemann, R

AU - Spinath, F M

AU - Angleitner, A

AU - Plomin, R

PY - 1997

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AB - Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires. We attempted to extend these findings using a selected extremes design and peer ratings. From a sample of 2085 individuals, each assessed on neuroticism by two independent peers, we selected 52 individuals from the top 5% and 54 individuals from the bottom 5%. No association was found for either a functional 44 bp insertion/deletion polymorphism in 5HTT regulatory sequence (5HTTLPR) or for a non-functional variable number tandem repeat 5HTT polymorphism.

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SP - 1301

EP - 1304

JO - Neuroreport

JF - Neuroreport

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The serotonin transporter gene and peer-rated neuroticism

Abstract

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