The sex ratio in amyotrophic lateral sclerosis: A population based study

Zita R. Manjaly; Kirsten M. Scott; Kumar Abhinav; Lokesh Wijesekera; Jeban Ganesalingam; Laura H. Goldstein; Anna Janssen; Andrew Dougherty; Emma Willey; Biba R. Stanton; Martin R. Turner; Mary-Ann Ampong; Mohammed Sakel; Richard W. Orrell; Robin Howard; Chris E. Shaw; P. Nigel Leigh; Ammar Al-Chalabi

doi:10.3109/17482961003610853

The sex ratio in amyotrophic lateral sclerosis: A population based study

Zita R. Manjaly, Kirsten M. Scott, Kumar Abhinav, Lokesh Wijesekera, Jeban Ganesalingam, Laura H. Goldstein, Anna Janssen, Andrew Dougherty, Emma Willey, Biba R. Stanton, Martin R. Turner, Mary-Ann Ampong, Mohammed Sakel, Richard W. Orrell, Robin Howard, Chris E. Shaw, P. Nigel Leigh, Ammar Al-Chalabi

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Abstract

Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role.

Original language	English
Pages (from-to)	439 - 442
Number of pages	4
Journal	Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume	11
Issue number	5
DOIs	https://doi.org/10.3109/17482961003610853
Publication status	Published - Oct 2010

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Manjaly, Z. R., Scott, K. M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L. H., Janssen, A., Dougherty, A., Willey, E., Stanton, B. R., Turner, M. R., Ampong, M.-A., Sakel, M., Orrell, R. W., Howard, R., Shaw, C. E., Leigh, P. N., & Al-Chalabi, A. (2010). The sex ratio in amyotrophic lateral sclerosis: A population based study. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 11(5), 439 - 442. https://doi.org/10.3109/17482961003610853

@article{f6bf9de3dc844f5aa788d988118201a0,

title = "The sex ratio in amyotrophic lateral sclerosis: A population based study",

abstract = "Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role.",

author = "Manjaly, {Zita R.} and Scott, {Kirsten M.} and Kumar Abhinav and Lokesh Wijesekera and Jeban Ganesalingam and Goldstein, {Laura H.} and Anna Janssen and Andrew Dougherty and Emma Willey and Stanton, {Biba R.} and Turner, {Martin R.} and Mary-Ann Ampong and Mohammed Sakel and Orrell, {Richard W.} and Robin Howard and Shaw, {Chris E.} and Leigh, {P. Nigel} and Ammar Al-Chalabi",

year = "2010",

month = oct,

doi = "10.3109/17482961003610853",

language = "English",

volume = "11",

pages = "439 -- 442",

journal = "Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders",

issn = "2167-9223",

publisher = "Taylor & Francis",

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Manjaly, ZR, Scott, KM, Abhinav, K, Wijesekera, L , Ganesalingam, J , Goldstein, LH , Janssen, A , Dougherty, A, Willey, E, Stanton, BR, Turner, MR, Ampong, M-A, Sakel, M, Orrell, RW, Howard, R, Shaw, CE, Leigh, PN & Al-Chalabi, A 2010, 'The sex ratio in amyotrophic lateral sclerosis: A population based study', Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, vol. 11, no. 5, pp. 439 - 442. https://doi.org/10.3109/17482961003610853

TY - JOUR

T1 - The sex ratio in amyotrophic lateral sclerosis: A population based study

AU - Manjaly, Zita R.

AU - Scott, Kirsten M.

AU - Abhinav, Kumar

AU - Wijesekera, Lokesh

AU - Ganesalingam, Jeban

AU - Goldstein, Laura H.

AU - Janssen, Anna

AU - Dougherty, Andrew

AU - Willey, Emma

AU - Stanton, Biba R.

AU - Turner, Martin R.

AU - Ampong, Mary-Ann

AU - Sakel, Mohammed

AU - Orrell, Richard W.

AU - Howard, Robin

AU - Shaw, Chris E.

AU - Leigh, P. Nigel

AU - Al-Chalabi, Ammar

PY - 2010/10

Y1 - 2010/10

N2 - Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role.

AB - Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role.

U2 - 10.3109/17482961003610853

DO - 10.3109/17482961003610853

M3 - Article

SN - 2167-9223

SN - 1471-180X

VL - 11

SP - 439

EP - 442

JO - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

JF - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

IS - 5

ER -

The sex ratio in amyotrophic lateral sclerosis: A population based study

Abstract

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