Abstract
Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.
Original language | English |
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Pages (from-to) | 15 |
Journal | Genome medicine |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 20 Feb 2015 |