The use of intracellular single-chain antibody fragments to specifically inhibit cytokine secretion

K C Daniel; J A Gaken; F Farzaneh; D M Kemeny

doi:10.1159/000053715

The use of intracellular single-chain antibody fragments to specifically inhibit cytokine secretion

K C Daniel, J A Gaken, F Farzaneh, D M Kemeny

King's College London

Research output: Contribution to journal › Conference paper

1 Citation (Scopus)

Abstract

Intracellular single-chain antibody fragments (intrabodies) are a novel way to achieve post-translational down-regulation of genes. However, their application to secreted proteins has not been studied in great detail. T cells secrete a wide array of cytokines that mediate their different effector functions and present an ideal application for this technology.

Original language	English
Pages (from-to)	216 - 217
Number of pages	2
Journal	International Archives of Allergy and Immunology
Volume	124
Issue number	1-3
DOIs	https://doi.org/10.1159/000053715
Publication status	Published - 2001
Event	23rd Symposium of the Collegium Internationale Allergologicum (CIA 2000) - HAKONE, Japan Duration: 1 Jan 2001 → …

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abstract = "Intracellular single-chain antibody fragments (intrabodies) are a novel way to achieve post-translational down-regulation of genes. However, their application to secreted proteins has not been studied in great detail. T cells secrete a wide array of cytokines that mediate their different effector functions and present an ideal application for this technology.",

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AU - Gaken, J A

AU - Farzaneh, F

AU - Kemeny, D M

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AB - Intracellular single-chain antibody fragments (intrabodies) are a novel way to achieve post-translational down-regulation of genes. However, their application to secreted proteins has not been studied in great detail. T cells secrete a wide array of cytokines that mediate their different effector functions and present an ideal application for this technology.

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DO - 10.1159/000053715

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VL - 124

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JO - International Archives of Allergy and Immunology

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IS - 1-3

T2 - 23rd Symposium of the Collegium Internationale Allergologicum (CIA 2000)

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The use of intracellular single-chain antibody fragments to specifically inhibit cytokine secretion

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