TY - JOUR
T1 - The vision-related burden of dry eye
AU - Morthen, Mathias Kaurstad
AU - Magno, Morten Schjerven
AU - Utheim, Tor Paaske
AU - Snieder, Harold
AU - Jansonius, Nomdo
AU - Hammond, Christopher J.
AU - Vehof, Jelle
N1 - Funding Information:
The authors wish to acknowledge the study participants, the services of the Lifelines Cohort Study, and the contributing research centres delivering data to Lifelines. The Lifelines Biobank initiative has been made possible by subsidy from the Dutch Ministry of Health, Welfare, and Sport, the Dutch Ministry of Economic Affairs, the University Medical Center Groningen (UMCG the Netherlands), University of Groningen, and the Northern Provinces of the Netherlands. The sponsor or funding organization had no role in the design or conduct of this research.
Publisher Copyright:
© 2021 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - Purpose: To investigate the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL) at population level. Methods: DED and VR-QoL were assessed in 89,022 participants (18–96 years, 59% female) from the Dutch population-based Lifelines cohort using the Women's Health study (WHS) and Visual function 25 (VFQ25) questionnaires. The relationship between DED and compromised VR-QoL was assessed with logistic regression, corrected for age, sex, BMI, income, education, smoking, and 55 comorbidities. Results: 9.1% of participants had DED. The participants with DED had higher risk of compromised average of ten domains of VR-QoL (OR 3.12 (95% CI 2.98–3.27) corrected for age, sex, BMI, income, smoking, and 55 comorbidities). Increasing symptom frequency was highly associated with decreasing VR-QoL (P < 0.0005). In all VR-QoL domains, including measures of daily visual function and emotional well-being, DED was clearly associated with compromised VR-QoL. Compared to macular degeneration, glaucoma, retinal detachment, and allergic conjunctivitis, DED presented similar or higher risks for compromised score on all VR-QoL domains. The population-attributable fraction of DED for compromised general vision exceeded that of other eye diseases investigated, especially in the younger age groups. Conclusion: DED is associated with reductions in all domains of VR-QoL, also after correction for associated comorbidities. We found that DED imposes an extensive population burden regarding compromised VR-QoL due to its high prevalence and substantial impact on VR-QoL, higher than that for other common vision-affecting eye disorders. Our results emphasize the importance of recognizing DED as a serious disorder from both patient and public health perspectives.
AB - Purpose: To investigate the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL) at population level. Methods: DED and VR-QoL were assessed in 89,022 participants (18–96 years, 59% female) from the Dutch population-based Lifelines cohort using the Women's Health study (WHS) and Visual function 25 (VFQ25) questionnaires. The relationship between DED and compromised VR-QoL was assessed with logistic regression, corrected for age, sex, BMI, income, education, smoking, and 55 comorbidities. Results: 9.1% of participants had DED. The participants with DED had higher risk of compromised average of ten domains of VR-QoL (OR 3.12 (95% CI 2.98–3.27) corrected for age, sex, BMI, income, smoking, and 55 comorbidities). Increasing symptom frequency was highly associated with decreasing VR-QoL (P < 0.0005). In all VR-QoL domains, including measures of daily visual function and emotional well-being, DED was clearly associated with compromised VR-QoL. Compared to macular degeneration, glaucoma, retinal detachment, and allergic conjunctivitis, DED presented similar or higher risks for compromised score on all VR-QoL domains. The population-attributable fraction of DED for compromised general vision exceeded that of other eye diseases investigated, especially in the younger age groups. Conclusion: DED is associated with reductions in all domains of VR-QoL, also after correction for associated comorbidities. We found that DED imposes an extensive population burden regarding compromised VR-QoL due to its high prevalence and substantial impact on VR-QoL, higher than that for other common vision-affecting eye disorders. Our results emphasize the importance of recognizing DED as a serious disorder from both patient and public health perspectives.
KW - Driving
KW - Dry eye disease
KW - Population attributable fraction
KW - Vision-related quality of life (VR-QoL)
KW - Visual function
UR - http://www.scopus.com/inward/record.url?scp=85119211275&partnerID=8YFLogxK
U2 - 10.1016/j.jtos.2021.10.007
DO - 10.1016/j.jtos.2021.10.007
M3 - Article
AN - SCOPUS:85119211275
SN - 1542-0124
VL - 23
SP - 207
EP - 215
JO - OCULAR SURFACE
JF - OCULAR SURFACE
ER -
