The Wnt/ b -Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cell

Tsz Kan Fung; Anskar YH Leung; Chi Wai So

doi:10.1007/978-94-007-6262-6_14

The Wnt/ b -Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cell

Tsz Kan Fung, Anskar YH Leung, Chi Wai So

University of Hong Kong

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Components of the canonical Wnt/β-catenin signaling pathway are frequently mutated in cancer, and their deregulation has also been recently associated with the development of cancer stem cells (CSCs). Elevation of β-catenin activity is critical for blast transformation and drug resistant property of the stem cells in both chronic and acute myeloid leukemia, although the underlying mechanisms are still largely unknown. In this chapter, we will focus on the role of Wnt/β-catenin pathway in normal hematopoietic and leukemic stem cells. We will also review currently available small molecule inhibitors that target the canonical Wnt signaling, and propose their potential applications in combination with chemotherapy for cancer treatment.

Original language	English
Title of host publication	Stem Cells and Cancer Stem Cells
Subtitle of host publication	Therapeutic Applications in Disease and Injury
Editors	M.A. Hayat
Publisher	Springer
Number of pages	298
Volume	10
ISBN (Print)	9400762623, 9789400762626, 9789400762619, 9400762615
DOIs	https://doi.org/10.1007/978-94-007-6262-6_14
Publication status	Published - 2013

Publication series

Name	Stem cells and cancer stem cells
Volume	volume 10

Keywords

Stem Cells
Stem Cell Transplantation
Stem cells
Cancer cells
Neoplastic Stem Cells
MEDICAL

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-94-007-6262-6_14

Cite this

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abstract = "Components of the canonical Wnt/β-catenin signaling pathway are frequently mutated in cancer, and their deregulation has also been recently associated with the development of cancer stem cells (CSCs). Elevation of β-catenin activity is critical for blast transformation and drug resistant property of the stem cells in both chronic and acute myeloid leukemia, although the underlying mechanisms are still largely unknown. In this chapter, we will focus on the role of Wnt/β-catenin pathway in normal hematopoietic and leukemic stem cells. We will also review currently available small molecule inhibitors that target the canonical Wnt signaling, and propose their potential applications in combination with chemotherapy for cancer treatment.",

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author = "Fung, {Tsz Kan} and Leung, {Anskar YH} and So, {Chi Wai}",

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The Wnt/ b -Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cell. / Fung, Tsz Kan; Leung, Anskar YH; So, Chi Wai.
Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury. ed. / M.A. Hayat. Vol. 10 Springer, 2013. (Stem cells and cancer stem cells; Vol. volume 10).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Fung, Tsz Kan

AU - Leung, Anskar YH

AU - So, Chi Wai

N1 - Includes bibliographical references and index

PY - 2013

Y1 - 2013

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AB - Components of the canonical Wnt/β-catenin signaling pathway are frequently mutated in cancer, and their deregulation has also been recently associated with the development of cancer stem cells (CSCs). Elevation of β-catenin activity is critical for blast transformation and drug resistant property of the stem cells in both chronic and acute myeloid leukemia, although the underlying mechanisms are still largely unknown. In this chapter, we will focus on the role of Wnt/β-catenin pathway in normal hematopoietic and leukemic stem cells. We will also review currently available small molecule inhibitors that target the canonical Wnt signaling, and propose their potential applications in combination with chemotherapy for cancer treatment.

KW - Stem Cells

KW - Stem Cell Transplantation

KW - Stem cells

KW - Cancer cells

KW - Neoplastic Stem Cells

KW - MEDICAL

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DO - 10.1007/978-94-007-6262-6_14

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SN - 9789400762619

SN - 9400762615

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T3 - Stem cells and cancer stem cells

BT - Stem Cells and Cancer Stem Cells

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PB - Springer

ER -

The Wnt/ b -Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cell

Abstract

Publication series

Keywords

UN SDGs

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