TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system

G. Rindi; G. Klöppel; H. Alhman; M. Caplin; A. Couvelard; W. W. De Herder; B. Erikssson; A. Falchetti; M. Falconi; P. Komminoth; M. Körner; J. M. Lopes; A. M. McNicol; O. Nilsson; A. Perren; A. Scarpa; J. Y. Scoazec; B. Wiedenmann; R. Arnold; W. O. Bechstein; G. Cadiot; E. Christ; D. Chung; G. Delle Fave; D. Ferone; P. Goretzki; D. Gross; D. Hochhauser; R. Hyrdel; R. Jensen; G. Kaltsas; F. Keletimur; R. Kianmanesh; W. Knapp; U. P. Knigge; B. Kos-Kuda; L. Kvols; D. Kwekkeboom; V. Lewington; R. Manfredi; E. Mitry; B. Niederle; G. Nikou; K. Öberg; J. O'Connor; D. O'Toole; S. Pauwels; M. Pavel; U. Plöckinger; J. Ramage; J. Ricke; P. Ruszniewski; R. Salazar; A. Sauvanet; M. I. Sevilla Garcia; T. A. Steinmüller; A. Sundin; B. Taal; E. Van Cutsem; M. P. Vullierme; S. Wildi; J. C. Yao

doi:10.1007/s00428-006-0250-1

TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system

G. Rindi^*, G. Klöppel, H. Alhman, M. Caplin, A. Couvelard, W. W. De Herder, B. Erikssson, A. Falchetti, M. Falconi, P. Komminoth, M. Körner, J. M. Lopes, A. M. McNicol, O. Nilsson, A. Perren, A. Scarpa, J. Y. Scoazec, B. Wiedenmann, R. Arnold, W. O. BechsteinG. Cadiot, E. Christ, D. Chung, G. Delle Fave, D. Ferone, P. Goretzki, D. Gross, D. Hochhauser, R. Hyrdel, R. Jensen, G. Kaltsas, F. Keletimur, R. Kianmanesh, W. Knapp, U. P. Knigge, B. Kos-Kuda, L. Kvols, D. Kwekkeboom, V. Lewington, R. Manfredi, E. Mitry, B. Niederle, G. Nikou, K. Öberg, J. O'Connor, D. O'Toole, S. Pauwels, M. Pavel, U. Plöckinger, J. Ramage, J. Ricke, P. Ruszniewski, R. Salazar, A. Sauvanet, M. I. Sevilla Garcia, T. A. Steinmüller, A. Sundin, B. Taal, E. Van Cutsem, M. P. Vullierme, S. Wildi, J. C. Yao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

Original language	English
Pages (from-to)	395-401
Number of pages	7
Journal	Virchows Archiv
Volume	449
Issue number	4
DOIs	https://doi.org/10.1007/s00428-006-0250-1
Publication status	Published - Oct 2006

Keywords

Grading
Gut
Ki-67 index
Mitotic index
Neuroendocrine tumors
Pancreas
Staging
TNM

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10.1007/s00428-006-0250-1

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Rindi, G., Klöppel, G., Alhman, H., Caplin, M., Couvelard, A., De Herder, W. W., Erikssson, B., Falchetti, A., Falconi, M., Komminoth, P., Körner, M., Lopes, J. M., McNicol, A. M., Nilsson, O., Perren, A., Scarpa, A., Scoazec, J. Y., Wiedenmann, B., Arnold, R., ... Yao, J. C. (2006). TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Archiv, 449(4), 395-401. https://doi.org/10.1007/s00428-006-0250-1

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abstract = "The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.",

keywords = "Grading, Gut, Ki-67 index, Mitotic index, Neuroendocrine tumors, Pancreas, Staging, TNM",

author = "G. Rindi and G. Kl{\"o}ppel and H. Alhman and M. Caplin and A. Couvelard and {De Herder}, {W. W.} and B. Erikssson and A. Falchetti and M. Falconi and P. Komminoth and M. K{\"o}rner and Lopes, {J. M.} and McNicol, {A. M.} and O. Nilsson and A. Perren and A. Scarpa and Scoazec, {J. Y.} and B. Wiedenmann and R. Arnold and Bechstein, {W. O.} and G. Cadiot and E. Christ and D. Chung and {Delle Fave}, G. and D. Ferone and P. Goretzki and D. Gross and D. Hochhauser and R. Hyrdel and R. Jensen and G. Kaltsas and F. Keletimur and R. Kianmanesh and W. Knapp and Knigge, {U. P.} and B. Kos-Kuda and L. Kvols and D. Kwekkeboom and V. Lewington and R. Manfredi and E. Mitry and B. Niederle and G. Nikou and K. {\"O}berg and J. O'Connor and D. O'Toole and S. Pauwels and M. Pavel and U. Pl{\"o}ckinger and J. Ramage and J. Ricke and P. Ruszniewski and R. Salazar and A. Sauvanet and {Sevilla Garcia}, {M. I.} and Steinm{\"u}ller, {T. A.} and A. Sundin and B. Taal and {Van Cutsem}, E. and Vullierme, {M. P.} and S. Wildi and Yao, {J. C.}",

year = "2006",

month = oct,

doi = "10.1007/s00428-006-0250-1",

language = "English",

volume = "449",

pages = "395--401",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer",

number = "4",

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Rindi, G, Klöppel, G, Alhman, H, Caplin, M, Couvelard, A, De Herder, WW, Erikssson, B, Falchetti, A, Falconi, M, Komminoth, P, Körner, M, Lopes, JM, McNicol, AM, Nilsson, O, Perren, A, Scarpa, A, Scoazec, JY, Wiedenmann, B, Arnold, R, Bechstein, WO, Cadiot, G, Christ, E, Chung, D, Delle Fave, G, Ferone, D, Goretzki, P, Gross, D, Hochhauser, D, Hyrdel, R, Jensen, R, Kaltsas, G, Keletimur, F, Kianmanesh, R, Knapp, W, Knigge, UP, Kos-Kuda, B, Kvols, L, Kwekkeboom, D, Lewington, V, Manfredi, R, Mitry, E, Niederle, B, Nikou, G, Öberg, K, O'Connor, J, O'Toole, D, Pauwels, S, Pavel, M, Plöckinger, U, Ramage, J, Ricke, J, Ruszniewski, P, Salazar, R, Sauvanet, A, Sevilla Garcia, MI, Steinmüller, TA, Sundin, A, Taal, B, Van Cutsem, E, Vullierme, MP, Wildi, S & Yao, JC 2006, 'TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system', Virchows Archiv, vol. 449, no. 4, pp. 395-401. https://doi.org/10.1007/s00428-006-0250-1

TY - JOUR

T1 - TNM staging of foregut (neuro)endocrine tumors

T2 - A consensus proposal including a grading system

AU - Rindi, G.

AU - Klöppel, G.

AU - Alhman, H.

AU - Caplin, M.

AU - Couvelard, A.

AU - De Herder, W. W.

AU - Erikssson, B.

AU - Falchetti, A.

AU - Falconi, M.

AU - Komminoth, P.

AU - Körner, M.

AU - Lopes, J. M.

AU - McNicol, A. M.

AU - Nilsson, O.

AU - Perren, A.

AU - Scarpa, A.

AU - Scoazec, J. Y.

AU - Wiedenmann, B.

AU - Arnold, R.

AU - Bechstein, W. O.

AU - Cadiot, G.

AU - Christ, E.

AU - Chung, D.

AU - Delle Fave, G.

AU - Ferone, D.

AU - Goretzki, P.

AU - Gross, D.

AU - Hochhauser, D.

AU - Hyrdel, R.

AU - Jensen, R.

AU - Kaltsas, G.

AU - Keletimur, F.

AU - Kianmanesh, R.

AU - Knapp, W.

AU - Knigge, U. P.

AU - Kos-Kuda, B.

AU - Kvols, L.

AU - Kwekkeboom, D.

AU - Lewington, V.

AU - Manfredi, R.

AU - Mitry, E.

AU - Niederle, B.

AU - Nikou, G.

AU - Öberg, K.

AU - O'Connor, J.

AU - O'Toole, D.

AU - Pauwels, S.

AU - Pavel, M.

AU - Plöckinger, U.

AU - Ramage, J.

AU - Ricke, J.

AU - Ruszniewski, P.

AU - Salazar, R.

AU - Sauvanet, A.

AU - Sevilla Garcia, M. I.

AU - Steinmüller, T. A.

AU - Sundin, A.

AU - Taal, B.

AU - Van Cutsem, E.

AU - Vullierme, M. P.

AU - Wildi, S.

AU - Yao, J. C.

PY - 2006/10

Y1 - 2006/10

N2 - The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

AB - The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

KW - Grading

KW - Gut

KW - Ki-67 index

KW - Mitotic index

KW - Neuroendocrine tumors

KW - Pancreas

KW - Staging

KW - TNM

UR - http://www.scopus.com/inward/record.url?scp=33749032826&partnerID=8YFLogxK

U2 - 10.1007/s00428-006-0250-1

DO - 10.1007/s00428-006-0250-1

M3 - Article

C2 - 16967267

AN - SCOPUS:33749032826

SN - 0945-6317

VL - 449

SP - 395

EP - 401

JO - Virchows Archiv

JF - Virchows Archiv

IS - 4

ER -

TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system

Abstract

Keywords

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