Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

Elise Roze; Polly A Harris; Gareth Ball; Leire Zubiaurre Elorza; Rodrigo M Braga; Joanna M Allsop; Nazakat Merchant; Emma Porter; Tomoki Arichi; A David Edwards; Mary A Rutherford; Frances M Cowan; Serena J Counsell

doi:10.1007/s00234-011-0969-5

Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

Elise Roze, Polly A Harris, Gareth Ball, Leire Zubiaurre Elorza, Rodrigo M Braga, Joanna M Allsop, Nazakat Merchant, Emma Porter, Tomoki Arichi, A David Edwards, Mary A Rutherford, Frances M Cowan, Serena J Counsell

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Abstract

Introduction
Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.

Methods
We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.

Results
Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.

Conclusion
Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.

Original language	English
Pages (from-to)	507-516
Number of pages	10
Journal	Neuroradiology
Volume	54
Issue number	5
DOIs	https://doi.org/10.1007/s00234-011-0969-5
Publication status	Published - May 2012

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Roze, E., Harris, P. A., Ball, G., Elorza, L. Z., Braga, R. M., Allsop, J. M., Merchant, N., Porter, E., Arichi, T., Edwards, A. D., Rutherford, M. A., Cowan, F. M., & Counsell, S. J. (2012). Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development. Neuroradiology, 54(5), 507-516. https://doi.org/10.1007/s00234-011-0969-5

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title = "Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development",

abstract = "IntroductionOur aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.MethodsWe studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.ResultsConventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.ConclusionConventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.",

author = "Elise Roze and Harris, {Polly A} and Gareth Ball and Elorza, {Leire Zubiaurre} and Braga, {Rodrigo M} and Allsop, {Joanna M} and Nazakat Merchant and Emma Porter and Tomoki Arichi and Edwards, {A David} and Rutherford, {Mary A} and Cowan, {Frances M} and Counsell, {Serena J}",

year = "2012",

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doi = "10.1007/s00234-011-0969-5",

language = "English",

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Roze, E, Harris, PA, Ball, G, Elorza, LZ, Braga, RM, Allsop, JM, Merchant, N, Porter, E, Arichi, T, Edwards, AD , Rutherford, MA, Cowan, FM & Counsell, SJ 2012, 'Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development', Neuroradiology, vol. 54, no. 5, pp. 507-516. https://doi.org/10.1007/s00234-011-0969-5

TY - JOUR

T1 - Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

AU - Roze, Elise

AU - Harris, Polly A

AU - Ball, Gareth

AU - Elorza, Leire Zubiaurre

AU - Braga, Rodrigo M

AU - Allsop, Joanna M

AU - Merchant, Nazakat

AU - Porter, Emma

AU - Arichi, Tomoki

AU - Edwards, A David

AU - Rutherford, Mary A

AU - Cowan, Frances M

AU - Counsell, Serena J

PY - 2012/5

Y1 - 2012/5

N2 - IntroductionOur aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.MethodsWe studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.ResultsConventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.ConclusionConventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.

AB - IntroductionOur aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.MethodsWe studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.ResultsConventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.ConclusionConventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.

U2 - 10.1007/s00234-011-0969-5

DO - 10.1007/s00234-011-0969-5

M3 - Article

C2 - 22006424

SN - 0028-3940

VL - 54

SP - 507

EP - 516

JO - Neuroradiology

JF - Neuroradiology

IS - 5

ER -

Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

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