Treatment of non-unions with bone defects: Which option and why?

O. Ashman; Mark Phillips

doi:10.1016/S0020-1383(13)70010-X

Treatment of non-unions with bone defects: Which option and why?

O. Ashman, Mark Phillips

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Bone defects associated with non-unions occur as a result of the initial insult or as a consequence of bone excision following non-union development. Historically management of this clinical scenario consisted mainly of amputation, which provided a short recovery period but a significant loss of limb function. Today treatment has evolved and multiple options are available for reconstruction of the bone defect. Broadly these are: bone shortening with lengthening later or bone transport and 'docking' (distraction osteogenesis based techniques); the use of vascularised and non-vascularised bone grafts; bone substitutes; stem cells; growth factors; scaffolds and gene therapy.

Original language	English
Pages (from-to)	S43-S45
Number of pages	3
Journal	Injury
Volume	44
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/S0020-1383(13)70010-X
Publication status	Published - Jan 2013

Keywords

Bone defects
Bone grafts
Bone shortening
Bone substitutes
Distraction osteogenesis
Gene therapy
Growth factors
Non-union
Scaffolds
Stem cells
biomaterial
growth factor
osteogenic protein 1
poly(methyl methacrylate)
procollagen C proteinase
tissue scaffold
transforming growth factor beta
article
bone allograft
bone defect
bone development
bone graft
bone matrix
bone prosthesis
callus
cells
cement spacer
chronic pain
debridement
distraction osteogenesis
donor site
external fixator
fibula graft
foreign body
fracture healing
fracture nonunion
gene therapy
human
joint contracture
leg lengthening
mesenchymal stem cell
microsurgery
ossification
osteoblast
osteotomy
patient compliance
peroneus nerve
priority journal
pseudarthrosis
reamer
soft tissue defect
stem cell
stress fracture
tissue engineering
trabecular bone
vascularization
Amputation
Bone Diseases
Bone Lengthening
Bone Regeneration
Bone Transplantation
Fractures, Ununited
Genetic Therapy
Humans
Osteogenesis, Distraction
Patient Selection
Tissue Engineering
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0020-1383(13)70010-X

Cite this

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abstract = "Bone defects associated with non-unions occur as a result of the initial insult or as a consequence of bone excision following non-union development. Historically management of this clinical scenario consisted mainly of amputation, which provided a short recovery period but a significant loss of limb function. Today treatment has evolved and multiple options are available for reconstruction of the bone defect. Broadly these are: bone shortening with lengthening later or bone transport and 'docking' (distraction osteogenesis based techniques); the use of vascularised and non-vascularised bone grafts; bone substitutes; stem cells; growth factors; scaffolds and gene therapy.",

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author = "O. Ashman and Mark Phillips",

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doi = "10.1016/S0020-1383(13)70010-X",

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KW - Bone grafts

KW - Bone shortening

KW - Bone substitutes

KW - Distraction osteogenesis

KW - Gene therapy

KW - Growth factors

KW - Non-union

KW - Scaffolds

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DO - 10.1016/S0020-1383(13)70010-X

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SN - 0020-1383

VL - 44

SP - S43-S45

JO - Injury

JF - Injury

IS - SUPPL.1

ER -

Treatment of non-unions with bone defects: Which option and why?

Abstract

Keywords

UN SDGs

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