Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis

Matthew Seymour; Frank Pétavy; Flaminia Chiesa; Hayley Perry; Pauline T Lukey; Michael Binks; Philippe D Donatien; Andrew J Freidin; Robert J Eckersley; Catherine McClinton; Kathleen Heath; Slavica Prodanovic; Goran Radunovic; Nada Pilipovic; Nemanja Damjanov; Peter C Taylor

Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis

Matthew Seymour, Frank Pétavy, Flaminia Chiesa, Hayley Perry, Pauline T Lukey, Michael Binks, Philippe D Donatien, Andrew J Freidin, Robert J Eckersley, Catherine McClinton, Kathleen Heath, Slavica Prodanovic, Goran Radunovic, Nada Pilipovic, Nemanja Damjanov, Peter C Taylor

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA).

Original language	English
Pages (from-to)	254-61
Number of pages	8
Journal	Clinical and Experimental Rheumatology
Volume	30
Issue number	2
Publication status	E-pub ahead of print - 13 Apr 2012

Keywords

Serbia
Double-Blind Method
Humans
Sulfides
Arthritis, Rheumatoid
Metacarpophalangeal Joint
Aged
England
Predictive Value of Tests
Enzyme Inhibitors
Ultrasonography, Doppler
Prednisolone
Adult
Treatment Outcome
Disability Evaluation
Synovitis
Nitric Oxide Synthase Type II
Placebos
Middle Aged
Antirheumatic Agents
Time Factors
Female
Male

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Seymour, M., Pétavy, F., Chiesa, F., Perry, H., Lukey, P. T., Binks, M., Donatien, P. D., Freidin, A. J., Eckersley, R. J., McClinton, C., Heath, K., Prodanovic, S., Radunovic, G., Pilipovic, N., Damjanov, N., & Taylor, P. C. (2012). Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. Clinical and Experimental Rheumatology, 30(2), 254-61. Advance online publication.

Seymour, Matthew ; Pétavy, Frank ; Chiesa, Flaminia et al. / Ultrasonographic measures of synovitis in an early phase clinical trial : a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. In: Clinical and Experimental Rheumatology. 2012 ; Vol. 30, No. 2. pp. 254-61.

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title = "Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis",

abstract = "To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA).",

keywords = "Serbia, Double-Blind Method, Humans, Sulfides, Arthritis, Rheumatoid, Metacarpophalangeal Joint, Aged, England, Predictive Value of Tests, Enzyme Inhibitors, Ultrasonography, Doppler, Prednisolone, Adult, Treatment Outcome, Disability Evaluation, Synovitis, Nitric Oxide Synthase Type II, Placebos, Middle Aged, Antirheumatic Agents, Time Factors, Female, Male",

author = "Matthew Seymour and Frank P{\'e}tavy and Flaminia Chiesa and Hayley Perry and Lukey, {Pauline T} and Michael Binks and Donatien, {Philippe D} and Freidin, {Andrew J} and Eckersley, {Robert J} and Catherine McClinton and Kathleen Heath and Slavica Prodanovic and Goran Radunovic and Nada Pilipovic and Nemanja Damjanov and Taylor, {Peter C}",

year = "2012",

month = apr,

day = "13",

language = "English",

volume = "30",

pages = "254--61",

journal = "Clinical and Experimental Rheumatology",

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Seymour, M, Pétavy, F, Chiesa, F, Perry, H, Lukey, PT, Binks, M, Donatien, PD, Freidin, AJ, Eckersley, RJ, McClinton, C, Heath, K, Prodanovic, S, Radunovic, G, Pilipovic, N, Damjanov, N & Taylor, PC 2012, 'Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis', Clinical and Experimental Rheumatology, vol. 30, no. 2, pp. 254-61.

Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. / Seymour, Matthew; Pétavy, Frank; Chiesa, Flaminia et al.
In: Clinical and Experimental Rheumatology, Vol. 30, No. 2, 13.04.2012, p. 254-61.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ultrasonographic measures of synovitis in an early phase clinical trial

T2 - a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis

AU - Seymour, Matthew

AU - Pétavy, Frank

AU - Chiesa, Flaminia

AU - Perry, Hayley

AU - Lukey, Pauline T

AU - Binks, Michael

AU - Donatien, Philippe D

AU - Freidin, Andrew J

AU - Eckersley, Robert J

AU - McClinton, Catherine

AU - Heath, Kathleen

AU - Prodanovic, Slavica

AU - Radunovic, Goran

AU - Pilipovic, Nada

AU - Damjanov, Nemanja

AU - Taylor, Peter C

PY - 2012/4/13

Y1 - 2012/4/13

N2 - To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA).

AB - To test the sensitivity to change of ultrasonographic endpoints in early phase clinical trials in subjects with active rheumatoid arthritis (RA).

KW - Serbia

KW - Double-Blind Method

KW - Humans

KW - Sulfides

KW - Arthritis, Rheumatoid

KW - Metacarpophalangeal Joint

KW - Aged

KW - England

KW - Predictive Value of Tests

KW - Enzyme Inhibitors

KW - Ultrasonography, Doppler

KW - Prednisolone

KW - Adult

KW - Treatment Outcome

KW - Disability Evaluation

KW - Synovitis

KW - Nitric Oxide Synthase Type II

KW - Placebos

KW - Middle Aged

KW - Antirheumatic Agents

KW - Time Factors

KW - Female

KW - Male

M3 - Article

C2 - 22409880

SN - 0392-856X

VL - 30

SP - 254

EP - 261

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 2

ER -

Seymour M, Pétavy F, Chiesa F, Perry H, Lukey PT, Binks M et al. Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. Clinical and Experimental Rheumatology. 2012 Apr 13;30(2):254-61. Epub 2012 Apr 13.