Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

F Abate; A Adu-Amankwah; K A Ae-Ngibise; F Agbokey; V A Agyemang; C T Agyemang; C Akgun; J Ametepe; T Arichi; K P Asante; S Balaji; L Baljer; P J Basser; J Beauchemin; C Bennallick; Y Berhane; Y Boateng-Mensah; N J Bourke; L Bradford; Mmk Bruchhage; R Cano Lorente; P Cawley; M Cercignani; V D Sa; A de Canha; N de Navarro; D C Dean; J Delarosa; K A Donald; A Dvorak; A D Edwards; D Field; H Frail; B Freeman; T George; J Gholam; J Guerrero-Gonzalez; J V Hajnal; R Haque; W Hollander; Z Hoodbhoy; M Huentelman; S K Jafri; D K Jones; F Joubert; T Karaulanov; M P Kasaro; S Knackstedt; S Kolind; B Koshy; R Kravitz; S Lecurieux Lafayette; A C Lee; B Lena; N Lepore; M Linguraru; E Ljungberg; Z Lockart; E Loth; P Mannam; K M Masemola; R Moran; D Murphy; F L Nakwa; V Nankabirwa; C A Nelson; K North; S Nyame; R O Halloran; J O'Muircheartaigh; B F Oakley; H Odendaal; C M Ongeti; D Onyango; S A Oppong; F Padormo; D Parvez; T Paus; M S Pepper; K S Phiri; M Poorman; J E Ringshaw; J Rogers; M Rutherford; H Sabir; L Sacolick; M Seal; M L Sekoli; T Shama; K Siddiqui; N Sindano; M B Spelke; P E Springer; F E Suleman; P C Sundgren; R Teixeira; W Terekegn; M Traughber; M G Tuuli; J van Rensburg; F Váša; S Velaphi; P Velasco; I M Viljoen; M Vokhiwa; A Webb; C Weiant; N Wiley; P Wintermark; K Yibetal; Scl Deoni; Scr Williams

doi:10.1016/j.dcn.2024.101397

Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

F Abate, A Adu-Amankwah, K A Ae-Ngibise, F Agbokey, V A Agyemang, C T Agyemang, C Akgun, J Ametepe, T Arichi, K P Asante, S Balaji, L Baljer, P J Basser, J Beauchemin, C Bennallick, Y Berhane, Y Boateng-Mensah, N J Bourke, L Bradford, Mmk BruchhageR Cano Lorente, P Cawley, M Cercignani, V D Sa, A de Canha, N de Navarro, D C Dean, J Delarosa, K A Donald, A Dvorak, A D Edwards, D Field, H Frail, B Freeman, T George, J Gholam, J Guerrero-Gonzalez, J V Hajnal, R Haque, W Hollander, Z Hoodbhoy, M Huentelman, S K Jafri, D K Jones, F Joubert, T Karaulanov, M P Kasaro, S Knackstedt, S Kolind, B Koshy, R Kravitz, S Lecurieux Lafayette, A C Lee, B Lena, N Lepore, M Linguraru, E Ljungberg, Z Lockart, E Loth, P Mannam, K M Masemola, R Moran, D Murphy, F L Nakwa, V Nankabirwa, C A Nelson, K North, S Nyame, R O Halloran, J O'Muircheartaigh, B F Oakley, H Odendaal, C M Ongeti, D Onyango, S A Oppong, F Padormo, D Parvez, T Paus, M S Pepper, K S Phiri, M Poorman, J E Ringshaw, J Rogers, M Rutherford, H Sabir, L Sacolick, M Seal, M L Sekoli, T Shama, K Siddiqui, N Sindano, M B Spelke, P E Springer, F E Suleman, P C Sundgren, R Teixeira, W Terekegn, M Traughber, M G Tuuli, J van Rensburg, F Váša, S Velaphi, P Velasco, I M Viljoen, M Vokhiwa, A Webb, C Weiant, N Wiley, P Wintermark, K Yibetal, Scl Deoni, Scr Williams

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Abstract

Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.

Original language	English
Article number	101397
Pages (from-to)	101397
Journal	Developmental Cognitive Neuroscience
Volume	69
Early online date	31 May 2024
DOIs	https://doi.org/10.1016/j.dcn.2024.101397
Publication status	Published - Oct 2024

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10.1016/j.dcn.2024.101397

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Abate, F., Adu-Amankwah, A., Ae-Ngibise, K. A., Agbokey, F., Agyemang, V. A., Agyemang, C. T., Akgun, C., Ametepe, J., Arichi, T., Asante, K. P., Balaji, S., Baljer, L., Basser, P. J., Beauchemin, J., Bennallick, C., Berhane, Y., Boateng-Mensah, Y., Bourke, N. J., Bradford, L., ... Williams, S. (2024). Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings. Developmental Cognitive Neuroscience, 69, 101397. Article 101397. https://doi.org/10.1016/j.dcn.2024.101397

@article{f72d3d2af36e4d80865be655eb9c98ef,

title = "Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings",

abstract = "Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.",

author = "F Abate and A Adu-Amankwah and Ae-Ngibise, {K A} and F Agbokey and Agyemang, {V A} and Agyemang, {C T} and C Akgun and J Ametepe and T Arichi and Asante, {K P} and S Balaji and L Baljer and Basser, {P J} and J Beauchemin and C Bennallick and Y Berhane and Y Boateng-Mensah and Bourke, {N J} and L Bradford and Mmk Bruchhage and Lorente, {R Cano} and P Cawley and M Cercignani and {D Sa}, V and Canha, {A de} and Navarro, {N de} and Dean, {D C} and J Delarosa and Donald, {K A} and A Dvorak and Edwards, {A D} and D Field and H Frail and B Freeman and T George and J Gholam and J Guerrero-Gonzalez and Hajnal, {J V} and R Haque and W Hollander and Z Hoodbhoy and M Huentelman and Jafri, {S K} and Jones, {D K} and F Joubert and T Karaulanov and Kasaro, {M P} and S Knackstedt and S Kolind and B Koshy and R Kravitz and Lafayette, {S Lecurieux} and Lee, {A C} and B Lena and N Lepore and M Linguraru and E Ljungberg and Z Lockart and E Loth and P Mannam and Masemola, {K M} and R Moran and D Murphy and Nakwa, {F L} and V Nankabirwa and Nelson, {C A} and K North and S Nyame and {O Halloran}, R and J O'Muircheartaigh and Oakley, {B F} and H Odendaal and Ongeti, {C M} and D Onyango and Oppong, {S A} and F Padormo and D Parvez and T Paus and Pepper, {M S} and Phiri, {K S} and M Poorman and Ringshaw, {J E} and J Rogers and M Rutherford and H Sabir and L Sacolick and M Seal and Sekoli, {M L} and T Shama and K Siddiqui and N Sindano and Spelke, {M B} and Springer, {P E} and Suleman, {F E} and Sundgren, {P C} and R Teixeira and W Terekegn and M Traughber and Tuuli, {M G} and Rensburg, {J van} and F V{\'a}{\v s}a and S Velaphi and P Velasco and Viljoen, {I M} and M Vokhiwa and A Webb and C Weiant and N Wiley and P Wintermark and K Yibetal and Scl Deoni and Scr Williams",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = oct,

doi = "10.1016/j.dcn.2024.101397",

language = "English",

volume = "69",

pages = "101397",

journal = "Developmental Cognitive Neuroscience",

issn = "1878-9293",

publisher = "Elsevier BV",

}

Abate, F, Adu-Amankwah, A, Ae-Ngibise, KA, Agbokey, F, Agyemang, VA, Agyemang, CT, Akgun, C, Ametepe, J, Arichi, T, Asante, KP, Balaji, S, Baljer, L, Basser, PJ, Beauchemin, J, Bennallick, C, Berhane, Y, Boateng-Mensah, Y, Bourke, NJ, Bradford, L, Bruchhage, M, Lorente, RC, Cawley, P, Cercignani, M, D Sa, V, Canha, AD, Navarro, ND, Dean, DC, Delarosa, J, Donald, KA, Dvorak, A, Edwards, AD, Field, D, Frail, H, Freeman, B, George, T, Gholam, J, Guerrero-Gonzalez, J, Hajnal, JV, Haque, R, Hollander, W, Hoodbhoy, Z, Huentelman, M, Jafri, SK, Jones, DK, Joubert, F, Karaulanov, T, Kasaro, MP, Knackstedt, S, Kolind, S, Koshy, B, Kravitz, R, Lafayette, SL, Lee, AC, Lena, B, Lepore, N, Linguraru, M, Ljungberg, E, Lockart, Z, Loth, E, Mannam, P, Masemola, KM, Moran, R , Murphy, D, Nakwa, FL, Nankabirwa, V, Nelson, CA, North, K, Nyame, S, O Halloran, R, O'Muircheartaigh, J , Oakley, BF, Odendaal, H, Ongeti, CM, Onyango, D, Oppong, SA, Padormo, F, Parvez, D, Paus, T, Pepper, MS, Phiri, KS, Poorman, M, Ringshaw, JE, Rogers, J, Rutherford, M, Sabir, H, Sacolick, L, Seal, M, Sekoli, ML, Shama, T, Siddiqui, K, Sindano, N, Spelke, MB, Springer, PE, Suleman, FE, Sundgren, PC, Teixeira, R, Terekegn, W, Traughber, M, Tuuli, MG, Rensburg, JV, Váša, F, Velaphi, S, Velasco, P, Viljoen, IM, Vokhiwa, M, Webb, A, Weiant, C, Wiley, N, Wintermark, P, Yibetal, K, Deoni, S & Williams, S 2024, 'Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings', Developmental Cognitive Neuroscience, vol. 69, 101397, pp. 101397. https://doi.org/10.1016/j.dcn.2024.101397

TY - JOUR

T1 - Unity

T2 - A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

AU - Abate, F

AU - Adu-Amankwah, A

AU - Ae-Ngibise, K A

AU - Agbokey, F

AU - Agyemang, V A

AU - Agyemang, C T

AU - Akgun, C

AU - Ametepe, J

AU - Arichi, T

AU - Asante, K P

AU - Balaji, S

AU - Baljer, L

AU - Basser, P J

AU - Beauchemin, J

AU - Bennallick, C

AU - Berhane, Y

AU - Boateng-Mensah, Y

AU - Bourke, N J

AU - Bradford, L

AU - Bruchhage, Mmk

AU - Lorente, R Cano

AU - Cawley, P

AU - Cercignani, M

AU - D Sa, V

AU - Canha, A de

AU - Navarro, N de

AU - Dean, D C

AU - Delarosa, J

AU - Donald, K A

AU - Dvorak, A

AU - Edwards, A D

AU - Field, D

AU - Frail, H

AU - Freeman, B

AU - George, T

AU - Gholam, J

AU - Guerrero-Gonzalez, J

AU - Hajnal, J V

AU - Haque, R

AU - Hollander, W

AU - Hoodbhoy, Z

AU - Huentelman, M

AU - Jafri, S K

AU - Jones, D K

AU - Joubert, F

AU - Karaulanov, T

AU - Kasaro, M P

AU - Knackstedt, S

AU - Kolind, S

AU - Koshy, B

AU - Kravitz, R

AU - Lafayette, S Lecurieux

AU - Lee, A C

AU - Lena, B

AU - Lepore, N

AU - Linguraru, M

AU - Ljungberg, E

AU - Lockart, Z

AU - Loth, E

AU - Mannam, P

AU - Masemola, K M

AU - Moran, R

AU - Murphy, D

AU - Nakwa, F L

AU - Nankabirwa, V

AU - Nelson, C A

AU - North, K

AU - Nyame, S

AU - O Halloran, R

AU - O'Muircheartaigh, J

AU - Oakley, B F

AU - Odendaal, H

AU - Ongeti, C M

AU - Onyango, D

AU - Oppong, S A

AU - Padormo, F

AU - Parvez, D

AU - Paus, T

AU - Pepper, M S

AU - Phiri, K S

AU - Poorman, M

AU - Ringshaw, J E

AU - Rogers, J

AU - Rutherford, M

AU - Sabir, H

AU - Sacolick, L

AU - Seal, M

AU - Sekoli, M L

AU - Shama, T

AU - Siddiqui, K

AU - Sindano, N

AU - Spelke, M B

AU - Springer, P E

AU - Suleman, F E

AU - Sundgren, P C

AU - Teixeira, R

AU - Terekegn, W

AU - Traughber, M

AU - Tuuli, M G

AU - Rensburg, J van

AU - Váša, F

AU - Velaphi, S

AU - Velasco, P

AU - Viljoen, I M

AU - Vokhiwa, M

AU - Webb, A

AU - Weiant, C

AU - Wiley, N

AU - Wintermark, P

AU - Yibetal, K

AU - Deoni, Scl

AU - Williams, Scr

PY - 2024/10

Y1 - 2024/10

N2 - Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.

AB - Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.

UR - http://www.scopus.com/inward/record.url?scp=85198983866&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2024.101397

DO - 10.1016/j.dcn.2024.101397

M3 - Article

C2 - 39029330

SN - 1878-9293

VL - 69

SP - 101397

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

M1 - 101397

ER -

Unity: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

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