Use of pentoxifylline and tocopherol in the management of osteoradionecrosis

Vinod Patel; Yusuf Gadiwalla; Isabel Sassoon; Chris Sproat; Jerry Kwok; Mark McGurk

doi:10.1016/j.bjoms.2015.11.027

Use of pentoxifylline and tocopherol in the management of osteoradionecrosis

Vinod Patel, Yusuf Gadiwalla, Isabel Sassoon, Chris Sproat, Jerry Kwok, Mark McGurk^*

^*Corresponding author for this work

GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.

Original language	English
Pages (from-to)	342-345
Journal	British Journal of Oral and Maxillofacial Surgery
Volume	54
Issue number	3
Early online date	19 Jan 2016
DOIs	https://doi.org/10.1016/j.bjoms.2015.11.027
Publication status	Published - Apr 2016

Keywords

Osteoradionecrosis
Pentoxifylline
Tocopherol

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10.1016/j.bjoms.2015.11.027

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abstract = "Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.",

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AU - Patel, Vinod

AU - Gadiwalla, Yusuf

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AU - Sproat, Chris

AU - Kwok, Jerry

AU - McGurk, Mark

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N2 - Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.

AB - Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). The next stage would ideally be to incorporate the treatment in a randomised clinical trial against both standard antibiotic treatment and hyperbaric oxygen.

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Use of pentoxifylline and tocopherol in the management of osteoradionecrosis

Abstract

Keywords

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