TY - JOUR
T1 - Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
AU - Genetic Risk and Outcome of Psychosis (GROUP) consortium
AU - Calafato, Maria Stella
AU - Thygesen, Johan H
AU - Ranlund, Siri
AU - Zartaloudi, Eirini
AU - Cahn, Wiepke
AU - Crespo-Facorro, Benedicto
AU - Díez-Revuelta, Álvaro
AU - Di Forti, Marta
AU - Hall, Mei-Hua
AU - Iyegbe, Conrad
AU - Jablensky, Assen
AU - Kahn, Rene
AU - Kalaydjieva, Luba
AU - Kravariti, Eugenia
AU - Lin, Kuang
AU - McDonald, Colm
AU - McIntosh, Andrew M
AU - McQuillin, Andrew
AU - Picchioni, Marco
AU - Rujescu, Dan
AU - Shaikh, Madiha
AU - Toulopoulou, Timothea
AU - Os, Jim Van
AU - Vassos, Evangelos
AU - Walshe, Muriel
AU - Powell, John
AU - Lewis, Cathryn M
AU - Murray, Robin M
AU - Bramon, Elvira
PY - 2018/9
Y1 - 2018/9
N2 - BACKGROUND: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.METHOD: Using the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.RESULTS: Patients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.CONCLUSIONS: Although polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.Declaration of interestR.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
AB - BACKGROUND: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.METHOD: Using the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.RESULTS: Patients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.CONCLUSIONS: Although polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.Declaration of interestR.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
U2 - 10.1192/bjp.2018.89
DO - 10.1192/bjp.2018.89
M3 - Article
C2 - 30113282
SN - 0007-1250
VL - 213
SP - 535
EP - 541
JO - The British journal of psychiatry : the journal of mental science
JF - The British journal of psychiatry : the journal of mental science
IS - 3
ER -