Vitamin D and risk of CVD: A review of the evidence

Catherine M. Fry; Thomas A B Sanders

doi:10.1017/S0029665115000014

Vitamin D and risk of CVD: A review of the evidence

Catherine M. Fry^*, Thomas A B Sanders

^*Corresponding author for this work

Diabetes UK

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

This review summarises evidence for an association between vitamin D status and CVD and the mechanisms involved. Vitamin D₃ is predominantly provided by the action of UVB from sunlight on skin. Average UK diets supply 2-3 μg/d vitamin D but diets containing at least one portion of oily fish per week supply about 7 μg/d. Pharmacological doses of vitamin D₂ (bolus injection of 7500 μg or intakes >50 μg/d) result in a smaller increase in plasma 25(OH)D than those of D₃ but physiological doses 5-25 μg/d seem equivalent. Plasma 25(OH)D concentrations are also influenced by clothing, obesity and skin pigmentation. Up to 40% of the population have plasma 25(OH)D concentrations 2 and D₃ with CVD incidence as the primary outcome.

Original language	English
Pages (from-to)	245-257
Number of pages	13
Journal	Proceedings of the Nutrition Society
Volume	74
Issue number	3
DOIs	https://doi.org/10.1017/S0029665115000014
Publication status	Published - 21 Aug 2015

Keywords

Cardiovascular risk
Cholecalciferol
Ergocalciferol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0029665115000014

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abstract = "This review summarises evidence for an association between vitamin D status and CVD and the mechanisms involved. Vitamin D3 is predominantly provided by the action of UVB from sunlight on skin. Average UK diets supply 2-3 μg/d vitamin D but diets containing at least one portion of oily fish per week supply about 7 μg/d. Pharmacological doses of vitamin D2 (bolus injection of 7500 μg or intakes >50 μg/d) result in a smaller increase in plasma 25(OH)D than those of D3 but physiological doses 5-25 μg/d seem equivalent. Plasma 25(OH)D concentrations are also influenced by clothing, obesity and skin pigmentation. Up to 40% of the population have plasma 25(OH)D concentrations 2 and D3 with CVD incidence as the primary outcome.",

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AB - This review summarises evidence for an association between vitamin D status and CVD and the mechanisms involved. Vitamin D3 is predominantly provided by the action of UVB from sunlight on skin. Average UK diets supply 2-3 μg/d vitamin D but diets containing at least one portion of oily fish per week supply about 7 μg/d. Pharmacological doses of vitamin D2 (bolus injection of 7500 μg or intakes >50 μg/d) result in a smaller increase in plasma 25(OH)D than those of D3 but physiological doses 5-25 μg/d seem equivalent. Plasma 25(OH)D concentrations are also influenced by clothing, obesity and skin pigmentation. Up to 40% of the population have plasma 25(OH)D concentrations 2 and D3 with CVD incidence as the primary outcome.

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Vitamin D and risk of CVD: A review of the evidence

Abstract

Keywords

UN SDGs

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