Vitreomacular adhesion and neovascular age-related macular degeneration

Andrew R H Simpson; Robert Petrarca; Timothy L Jackson

doi:10.1016/j.survophthal.2012.01.011

Vitreomacular adhesion and neovascular age-related macular degeneration

Andrew R H Simpson, Robert Petrarca, Timothy L Jackson

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular ("wet") age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD.

Original language	English
Pages (from-to)	498-509
Number of pages	12
Journal	Survey of Ophthalmology
Volume	57
Issue number	6
DOIs	https://doi.org/10.1016/j.survophthal.2012.01.011
Publication status	Published - Nov 2012

Keywords

Eye Diseases
Humans
Ophthalmologic Surgical Procedures
Retinal Diseases
Tissue Adhesions
Tomography, Optical Coherence
Vitreous Body
Wet Macular Degeneration

Access to Document

10.1016/j.survophthal.2012.01.011

Cite this

@article{426299bedd7446f99596caa20d967e6e,

title = "Vitreomacular adhesion and neovascular age-related macular degeneration",

abstract = "We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular ({"}wet{"}) age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD.",

keywords = "Eye Diseases, Humans, Ophthalmologic Surgical Procedures, Retinal Diseases, Tissue Adhesions, Tomography, Optical Coherence, Vitreous Body, Wet Macular Degeneration",

author = "Simpson, {Andrew R H} and Robert Petrarca and Jackson, {Timothy L}",

year = "2012",

month = nov,

doi = "10.1016/j.survophthal.2012.01.011",

language = "English",

volume = "57",

pages = "498--509",

journal = "Survey of Ophthalmology",

issn = "0039-6257",

publisher = "Elsevier USA",

number = "6",

}

TY - JOUR

T1 - Vitreomacular adhesion and neovascular age-related macular degeneration

AU - Simpson, Andrew R H

AU - Petrarca, Robert

AU - Jackson, Timothy L

PY - 2012/11

Y1 - 2012/11

N2 - We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular ("wet") age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD.

AB - We explore the hypothesis that vitreomacular adhesion (VMA) and vitreomacular traction (VMT) play a role in the pathogenesis and clinical course of neovascular ("wet") age-related macular degeneration (AMD). Several biological theories are offered to explain this possible association, including direct tractional force, altered vitreous oxygenation, altered diffusion coefficients of intravitreal molecules, and alterations in the pharmacokinetics of intravitreal drugs. Release of VMT may improve the clinical course of neovascular AMD, and a few case series suggest that vitrectomy can lead to both a functional and anatomic improvement. A large, randomized, controlled clinical trial is underway, investigating pharmacologic release of VMA in eyes with neovascular AMD.

KW - Eye Diseases

KW - Humans

KW - Ophthalmologic Surgical Procedures

KW - Retinal Diseases

KW - Tissue Adhesions

KW - Tomography, Optical Coherence

KW - Vitreous Body

KW - Wet Macular Degeneration

U2 - 10.1016/j.survophthal.2012.01.011

DO - 10.1016/j.survophthal.2012.01.011

M3 - Article

C2 - 23068973

SN - 0039-6257

VL - 57

SP - 498

EP - 509

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

IS - 6

ER -

Vitreomacular adhesion and neovascular age-related macular degeneration

Abstract

Keywords

Access to Document

Fingerprint

Cite this