WASP-interacting protein (WIP): working in polymerisation and much more

I M Anton; G E Jones; F Wandosell; R Geha; N Ramesh

doi:10.1016/j.tcb.2007.08.005

WASP-interacting protein (WIP): working in polymerisation and much more

I M Anton, G E Jones, F Wandosell, R Geha, N Ramesh

Research output: Contribution to journal › Literature review › peer-review

71 Citations (Scopus)

Abstract

The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP

Original language	English
Pages (from-to)	555 - 562
Number of pages	8
Journal	TRENDS IN CELL BIOLOGY
Volume	17
Issue number	11
DOIs	https://doi.org/10.1016/j.tcb.2007.08.005
Publication status	Published - Nov 2007

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title = "WASP-interacting protein (WIP): working in polymerisation and much more",

abstract = "The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP",

author = "Anton, {I M} and Jones, {G E} and F Wandosell and R Geha and N Ramesh",

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journal = "TRENDS IN CELL BIOLOGY",

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T1 - WASP-interacting protein (WIP): working in polymerisation and much more

AU - Anton, I M

AU - Jones, G E

AU - Wandosell, F

AU - Geha, R

AU - Ramesh, N

PY - 2007/11

Y1 - 2007/11

N2 - The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP

AB - The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP

U2 - 10.1016/j.tcb.2007.08.005

DO - 10.1016/j.tcb.2007.08.005

M3 - Literature review

VL - 17

SP - 555

EP - 562

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

IS - 11

ER -

WASP-interacting protein (WIP): working in polymerisation and much more

Abstract

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