Research output per year
Research output per year
Personal profile
Research interests
I am interested in the immunology of and immunosuppression in B-CLL. I am currently looking at the involvement of the microenvironment in in B-CLL and specifically the effect of T cells and endothelial cells on the malignant clone. i am currently trying to create a basic model to study this invitro. My work involves and lots of tissue culture, flow cytometry, proliferation assays and anaysis of cytokines. I am moving onto immunofluorescence staining of Lymph nodes using multiple markers to study this in-vivo.
Research interests (short)
B-CLL, immunosupression in cancer, endothelial/T cell/B-CLL cell interactions, microenvironment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Andrea Pepper née Buggins is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T-cells
Townsend, W., Pasikowska, M., Yallop, D., Phillips, E. H., Patten, P. E. M., Salisbury, J. R., Marcus, R., Pepper, A. & Devereux, S., 2019, In: Haematologica.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)135 Downloads (Pure) -
Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration
Pasikowska, M., Walsby, E., Apollonio, B., Cuthill, K. M., Phillips, E. H., Coulter, E. M., Longhi, M. S., Ma, Y., Yallop, D., Barber, L. D., Patten, P., Fegan, C., Ramsay, A. G., Pepper, C., Devereux, S. & Buggins, A. G. S., 28 Jul 2016, In: Blood. 128, 4, p. 563-573 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)191 Downloads (Pure) -
Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition
Buggins, A. G. S., Pepper, C., Jones, C. H., Walsby, E. J., Forconi, F., Pratt, G., Devereux, S., Stevenson, F. K. & Fegan, C., 29 Mar 2015, In: Leukemia. 29, 3, p. 744-747 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)158 Downloads (Pure) -
Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia: Modeling CLL cell migration under shear
walsby, E., Buggins, A., Devereux, S., Jones, C., Pratt, G., Brennan, P., Fegan, C. & Pepper, C., 2014, (E-pub ahead of print) In: Blood. 29 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells
Hamilton, E., Pearce, L., Morgan, L., Robinson, S., Ware, V., Brennan, P., Thomas, N. S. B., Yallop, D., Devereux, S., Fegan, C., Pepper, C. & Buggins, A. G. S., Sept 2012, In: British Journal of Haematology. 158, 5, p. 589-599 11 p.Research output: Contribution to journal › Article › peer-review
44 Citations (Scopus)
Projects
- 23 Finished
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Evaluating the immunological characteristics and anti-tumour efficacy of allogeneic CD19-targeted CAR-T cells in B-cell malignancies
academic, A. (Primary Investigator), Patten, P. (Co-Investigator), Pepper née Buggins, A. (Co-Investigator) & Ramsay, A. (Co-Investigator)
8/08/2016 → 1/08/2019
Project: Research
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An Investigation into Toll like receptor levels and signalling in CLL and Lymphoma and potential utilisation for therapy delivery.
Pepper née Buggins, A. (Primary Investigator), Devereux, S. (Co-Investigator), Patten, P. (Co-Investigator) & Ramsay, A. (Co-Investigator)
1/02/2016 → 31/01/2019
Project: Research
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An investigation into Toll like receptors in lymphoma and whether they can be utilised as a drug delivery tool.
Pepper née Buggins, A. (Primary Investigator), Devereux, S. (Co-Investigator), Patten, P. (Co-Investigator) & Ramsay, A. (Co-Investigator)
1/06/2015 → 31/05/2018
Project: Research
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The Relationship Between B-Cell Receptor Expression and Function and Tumour Dynamics in Chronic Lymphocytic Leukaemia
Devereux, S. (Primary Investigator) & Pepper née Buggins, A. (Co-Investigator)
1/04/2015 → 12/05/2017
Project: Research
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An Investigation of the Lymph Node T-Cell Compartment of Follicular Lymphoma
Devereux, S. (Primary Investigator) & Pepper née Buggins, A. (Co-Investigator)
1/04/2014 → 30/04/2015
Project: Research
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Multiple referee's for Blood (Journal)
Pepper née Buggins, A. (Editor)
2011 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Clinical Cancer Research (Journal)
Pepper née Buggins, A. (Editor)
2011 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Multiple referee's for Blood (Journal)
Pepper née Buggins, A. (Editor)
2010 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Blood (Journal)
Pepper née Buggins, A. (Editor)
2009 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Immunobiology (Journal)
Pepper née Buggins, A. (Editor)
2008 → …Activity: Publication peer-review and editorial work › Publication peer-review