Research output per year
Research output per year
Personal profile
Research interests
The Mammary stem cell biology group focuses on characterization of normal and malignant mammary stem cells in order to elucidate their role in cancer initiation and progression.
Developing an experimental framework appropriate for the study of stem cells of human origin is one of the priorities of the group and an ongoing effort. Novel experimental systems are employed to understand the molecular mechanisms that govern cell fate decisions and to identify defects in these mechanisms that can lead to transformation. The ultimate goal of these studies is to develop clinical applications based on stem cell biology concepts and to explore their translational potential in cancer diagnosis, prognostication, therapy and prevention.
Research interests (short)
Biology of normal and malignant mammary stem cells
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Research output
- 6 Article
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Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
Schott, A. F., Landis, M. D., Dontu, G., Griffith, K. A., Layman, R. M., Krop, I., Paskett, L. A., Wong, H., Dobrolecki, L. E., Lewis, M. T., Froehlich, A. M., Paranilam, J., Hayes, D. F., Wicha, M. S. & Chang, J. C., 15 Mar 2013, In: Clinical Cancer Research. 19, 6, p. 1512-1524 13 p.Research output: Contribution to journal › Article › peer-review
230 Citations (Scopus) -
Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R. & Wicha, M. S., 15 Jan 2011, In: Cancer Research. 71, 2, p. 614 - 624 11 p.Research output: Contribution to journal › Article › peer-review
527 Citations (Scopus) -
Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
Charafe-Jauffret, E., Ginestier, C., Iovino, F., Tarpin, C., Diebel, M., Esterni, B., Houvenaeghel, G., Extra, J.-M., Bertucci, F., Jacquemier, J., Xerri, L., Dontu, G., Stassi, G., Xiao, Y., Barsky, S. H., Birnbaum, D., Viens, P. & Wicha, M. S., 1 Jan 2010, In: Clinical Cancer Research. 16, 1, p. 45 - 55 11 p.Research output: Contribution to journal › Article › peer-review
615 Citations (Scopus) -
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J.-L., Dontu, G. & Wicha, M. S., 1 Feb 2010, In: Journal of Clinical Investigation. 120, 2, p. 485 - 497 13 p.Research output: Contribution to journal › Article › peer-review
659 Citations (Scopus) -
Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis
Huang, E. H., Hynes, M. J., Zhang, T., Ginestier, C., Dontu, G., Appelman, H., Fields, J. Z., Wicha, M. S. & Boman, B. M., 15 Apr 2009, In: Cancer Research. 69, 8, p. 3382 - 3389 8 p.Research output: Contribution to journal › Article › peer-review
891 Citations (Scopus)