Research output per year
Research output per year
Personal profile
Research interests
The Mammary stem cell biology group focuses on characterization of normal and malignant mammary stem cells in order to elucidate their role in cancer initiation and progression.
Developing an experimental framework appropriate for the study of stem cells of human origin is one of the priorities of the group and an ongoing effort. Novel experimental systems are employed to understand the molecular mechanisms that govern cell fate decisions and to identify defects in these mechanisms that can lead to transformation. The ultimate goal of these studies is to develop clinical applications based on stem cell biology concepts and to explore their translational potential in cancer diagnosis, prognostication, therapy and prevention.
Research interests (short)
Biology of normal and malignant mammary stem cells
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Gabriela Dontu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Models of breast morphogenesis based on localization of stem cells in the developing mammary lobule
Honeth, G., Schiavinotto, T., Vaggi, F., Marlow, R., Kanno, T., Shinomiya, I., Lombardi, S., Buchupalli, B., Graham, R., Gazinska, P., Ramalingam, V., Burchell, J., Purushotham, A. D., Pinder, S. E., Csikasz-Nagy, A. & Dontu, G., 14 Apr 2015, In: Stem Cell Reports. 4, 4, p. 699-711 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)222 Downloads (Pure) -
Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium
Honeth, G., Lombardi, S., Ginestier, C., Hur, M., Marlow, R., Buchupalli, B., Shinomiya, I., Gazinska, P., Bombelli, S., Ramalingam, V., Purushotham, A. D., Pinder, S. E. & Dontu, G., 27 May 2014, In: Breast Cancer Research. 16, 3, 15 p., R52.Research output: Contribution to journal › Article › peer-review
Open Access41 Citations (Scopus) -
Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells
Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S., Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S. & Dontu, G., 3 Jun 2014, In: Stem Cell Reports. 2, 6, p. 780-793 14 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Citations (Scopus) -
A novel model of dormancy for bone metastatic breast cancer cells
Marlow, R., Honeth, G., Lombardi, S., Cariati, M., Hessey, S. M., Pipili, A., Mariotti, V., Buchupalli, B., Foster, K., Bonnet, D., Grigoriadis, A., Purushotham, A., Tutt, A. & Dontu, G., Dec 2013, In: Cancer Research. 73, 23, p. 6886-6899 14 p.Research output: Contribution to journal › Article › peer-review
105 Citations (Scopus) -
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
Schott, A. F., Landis, M. D., Dontu, G., Griffith, K. A., Layman, R. M., Krop, I., Paskett, L. A., Wong, H., Dobrolecki, L. E., Lewis, M. T., Froehlich, A. M., Paranilam, J., Hayes, D. F., Wicha, M. S. & Chang, J. C., 15 Mar 2013, In: Clinical Cancer Research. 19, 6, p. 1512-1524 13 p.Research output: Contribution to journal › Article › peer-review
237 Citations (Scopus)
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MetBC - Molecular characterization of the metastatic breast cancer stem cell niche
Dontu, G. (Primary Investigator)
Project: Research
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The role of O-linked glycosylation in breast cancer bone marrow metastasis
Burchell, J. (Primary Investigator) & Dontu, G. (Co-Investigator)
1/03/2013 → 31/08/2014
Project: Research
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A novel experiment system for modelling he breast cancer bone metastatic niche
Dontu, G. (Primary Investigator)
1/09/2012 → 31/08/2013
Project: Research
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The dynamics of tumour progression in breast cancer as manifested by recurrences and the possible link with the lipid metabolism
Van Hemelrijck, M. (Primary Investigator), Dontu, G. (Co-Investigator) & Holmberg, L. (Co-Investigator)
1/07/2012 → 30/06/2014
Project: Research
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Targeting growth hormone signalling in breast cancer stem/progenitor cells
Dontu, G. (Primary Investigator)
1/06/2012 → 31/05/2014
Project: Research