Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Sara Lombardi; Gabriella Honeth; Christophe Ginestier; Ireneusz Shinomiya; Rebecca Marlow; Bharath Buchupalli; Patrycja Gazinska; John Brown; Steven Catchpole; Suling Liu; Ariel Barkan; Max Wicha; Anand Purushotham; Joy Burchell; Sarah Pinder; Gabriela Dontu

doi:10.1016/j.stemcr.2014.05.005

Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Sara Lombardi, Gabriella Honeth, Christophe Ginestier, Ireneusz Shinomiya, Rebecca Marlow, Bharath Buchupalli, Patrycja Gazinska, John Brown, Steven Catchpole, Suling Liu, Ariel Barkan, Max Wicha, Anand Purushotham, Joy Burchell, Sarah Pinder, Gabriela Dontu^*

^*Corresponding author for this work

Comprehensive Cancer Centre

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

Original language	English
Pages (from-to)	780-793
Number of pages	14
Journal	Stem Cell Reports
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2014.05.005
Publication status	Published - 3 Jun 2014

Keywords

MAMMARY-GLAND DEVELOPMENT
CARCINOMA CELLS
LARON SYNDROME
CANCER-RISK
STEM-CELLS
MICE
GH
DEFICIENCY
EXPRESSION
DISORDERS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stemcr.2014.05.005

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Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S., Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S., & Dontu, G. (2014). Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells. Stem Cell Reports, 2(6), 780-793. https://doi.org/10.1016/j.stemcr.2014.05.005

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title = "Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells",

abstract = "Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.",

keywords = "MAMMARY-GLAND DEVELOPMENT, CARCINOMA CELLS, LARON SYNDROME, CANCER-RISK, STEM-CELLS, MICE, GH, DEFICIENCY, EXPRESSION, DISORDERS",

author = "Sara Lombardi and Gabriella Honeth and Christophe Ginestier and Ireneusz Shinomiya and Rebecca Marlow and Bharath Buchupalli and Patrycja Gazinska and John Brown and Steven Catchpole and Suling Liu and Ariel Barkan and Max Wicha and Anand Purushotham and Joy Burchell and Sarah Pinder and Gabriela Dontu",

year = "2014",

month = jun,

day = "3",

doi = "10.1016/j.stemcr.2014.05.005",

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journal = "Stem Cell Reports",

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Lombardi, S, Honeth, G, Ginestier, C, Shinomiya, I, Marlow, R, Buchupalli, B, Gazinska, P, Brown, J , Catchpole, S, Liu, S, Barkan, A, Wicha, M, Purushotham, A , Burchell, J , Pinder, S & Dontu, G 2014, 'Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells', Stem Cell Reports, vol. 2, no. 6, pp. 780-793. https://doi.org/10.1016/j.stemcr.2014.05.005

TY - JOUR

T1 - Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

AU - Lombardi, Sara

AU - Honeth, Gabriella

AU - Ginestier, Christophe

AU - Shinomiya, Ireneusz

AU - Marlow, Rebecca

AU - Buchupalli, Bharath

AU - Gazinska, Patrycja

AU - Brown, John

AU - Catchpole, Steven

AU - Liu, Suling

AU - Barkan, Ariel

AU - Wicha, Max

AU - Purushotham, Anand

AU - Burchell, Joy

AU - Pinder, Sarah

AU - Dontu, Gabriela

PY - 2014/6/3

Y1 - 2014/6/3

N2 - Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

AB - Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

KW - MAMMARY-GLAND DEVELOPMENT

KW - CARCINOMA CELLS

KW - LARON SYNDROME

KW - CANCER-RISK

KW - STEM-CELLS

KW - MICE

KW - GH

KW - DEFICIENCY

KW - EXPRESSION

KW - DISORDERS

U2 - 10.1016/j.stemcr.2014.05.005

DO - 10.1016/j.stemcr.2014.05.005

M3 - Article

SN - 2213-6711

VL - 2

SP - 780

EP - 793

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 6

ER -

Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

Abstract

Keywords

UN SDGs

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