Genevieve Lachance

2020

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

UK10K Consortium & Breen, G., 21 Jan 2020, In: Nature Communications. 10, 1, 357.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2019

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

International Multiple Sclerosis Genetics Consortium & ANZgene, IIBDGC, WTCCC2, 27 Sept 2019, In: Science. 365, 6460, eaav7188.

Research output: Contribution to journal › Article › peer-review

789 Citations (Scopus)

2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

CHARGE Inflammation Working Group, LifeLines Cohort Study, Rose, L. M., Wu, Y., Lin, H., Macé, A., Abbasi, A., Smith, A. V., Mueller, C., Zhao, J. H., Amini, M., Wilson, J. F., Jamshidi, Y., Uher, R., Hicks, A., Morris, A. P., Stacey, D., Eriksson, J., Chen, W.-M. & Li, X. & 39 others, Cheng, Y.-C., Zhao, J. H., Huang, H., Liu, Y., Huang, J., Joshi, P. K., Lehne, B., Stott, D. J., Menni, C., Peters, A., Smit, J. H., Williams, S. R., Campbell, H., Chen, Y.-D., James, A. L., Smith, E. N., Larsson, A., Wang, Y., Scott, W. R., Evans, D. M., Madden, P. A. F., Lachance, G., Clarke, R., Harris, T. B., Scott, R. A., Hicks, A., Li, J. Z., Chambers, J. C., Martin, N. G., Scott, R. A., Whitfield, J. B., Spector, T. D., Eriksson, J., Wilson, J. F., Palmer, L. J., Murray, S. S., Evans, D. M., Schmidt, H. & Smith, G. D., 1 Nov 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journal › Article › peer-review

271 Citations (Scopus)

2017

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Day, F. R., Thompson, D. J., Helgason, H., Chasman, D. I., Finucane, H., Sulem, P., Ruth, K. S., Whalen, S., Sarkar, A. K., Albrecht, E., Altmaier, E., Amini, M., Barbieri, C. M., Boutin, T., Campbell, A., Demerath, E., Giri, A., He, C., Hottenga, J. J. & Karlsson, R. & 196 others, Kolcic, I., Loh, P. R., Lunetta, K. L., Mangino, M., Marco, B., McMahon, G., Medland, S. E., Nolte, I. M., Noordam, R., Nutile, T., Paternoster, L., Perjakova, N., Porcu, E., Rose, L. M., Schraut, K. E., Segrè, A. V., Smith, A. V., Stolk, L., Teumer, A., Andrulis, I. L., Bandinelli, S., Beckmann, M. W., Benitez, J., Bergmann, S., Bochud, M., Boerwinkle, E., Bojesen, S. E., Bolla, M. K., Brand, J. S., Brauch, H., Brenner, H., Broer, L., Brüning, T., Buring, J. E., Campbell, H., Catamo, E., Chanock, S., Chenevix-Trench, G., Corre, T., Couch, F. J., Cousminer, D. L., Cox, A., Crisponi, L., Czene, K., Davey Smith, G., de Geus, E. J. C. N., de Mutsert, R., de Vivo, I., Dennis, J., Devilee, P., dos-Santos-Silva, I., Dunning, A. M., Eriksson, J. G., Fasching, P. A., Fernández-Rhodes, L., Ferrucci, L., Flesch-Janys, D., Franke, L., Gabrielson, M., Gandin, I., Giles, G. G., Grallert, H., Gudbjartsson, D. F., Guénel, P., Hall, P., Hallberg, E., Hamann, U., Harris, T. B., Hartman, C. A., Heiss, G., Hooning, M. J., Hopper, J. L., Hu, F., Hunter, D. J., Ikram, M. A., Im, H. K., Järvelin, M. R., Joshi, P. K., Karasik, D., Kellis, M., Kutalik, Z., LaChance, G., Lambrechts, D., Langenberg, C., Launer, L. J., Laven, J. S. E., Lenarduzzi, S., Li, J., Lind, P. A., Lindstrom, S., Liu, Y. M., Luan, J., Mägi, R., Mannermaa, A., Mbarek, H., McCarthy, M. I., Meisinger, C., Meitinger, T., Menni, C., Metspalu, A., Michailidou, K., Milani, L., Milne, R. L., Montgomery, G. W., Mulligan, A. M., Nalls, M. A., Navarro, P., Nevanlinna, H., Nyholt, D. R., Oldehinkel, A. J., O'Mara, T. A., Padmanabhan, S., Palotie, A., Pedersen, N., Peters, A., Peto, J., Pharoah, P. D. P., Pouta, A., Radice, P., Rahman, I., Ring, S. M., Robino, A., Rosendaal, F. R., Rudan, I., Rueedi, R., Ruggiero, D., Sala, C. F., Schmidt, M. K., Scott, R. A., Shah, M., Sorice, R., Southey, M. C., Sovio, U., Stampfer, M., Steri, M., Strauch, K., Tanaka, T., Tikkanen, E., Timpson, N. J., Traglia, M., Truong, T., Tyrer, J. P., Uitterlinden, A. G., Edwards, D. R. V., Vitart, V., Völker, U., Vollenweider, P., Wang, Q., Widen, E., van Dijk, K. W., Willemsen, G., Winqvist, R., Wolffenbuttel, B. H. R., Zhao, J. H., Zoledziewska, M., Zygmunt, M., Alizadeh, B. Z., Boomsma, D. I., Ciullo, M., Cucca, F., Esko, T., Franceschini, N., Gieger, C., Gudnason, V., Hayward, C., Kraft, P., Lawlor, D. A., Magnusson, P. K. E., Martin, N. G., Mook-Kanamori, D. O., Nohr, E. A., Polasek, O., Porteous, D., Price, A. L., Ridker, P. M., Snieder, H., Spector, T. D., Stöckl, D., Toniolo, D., Ulivi, S., Visser, J. A., Völzke, H., Wareham, N. J., Wilson, J. F., Spurdle, A. B., Thorsteindottir, U., Pollard, K. S., Easton, D. F., Tung, J. Y., Chang-Claude, J., Hinds, D., Murray, A., Murabito, J. M., Stefansson, K., Ong, K. K. & Perry, J. R. B., 24 Apr 2017, (E-pub ahead of print) In: Nature Genetics. p. 834-841

Research output: Contribution to journal › Article › peer-review

386 Citations (Scopus)

2016

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: An individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Silventoinen, K., Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Honda, C., Hjelmborg, J. B., Moller, S., Ooki, S., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K. J., Jang, K. L., Cozen, W. & Hwang, A. E. & 84 others, MacK, T. M., Gao, W., Yu, C., Li, L., Corley, R. P., Huibregtse, B. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J., Heikkila, K., Wardle, J., Llewellyn, C. H., Fisher, A., McAdams, T. A., Eley, T. C., Gregory, A. M., He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Stazi, M. A., Fagnani, C., D'Ippolito, C., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S. A., Klump, K. L., Silberg, J. L., Eaves, L. J., Maes, H. H., Krueger, R. F., McGue, M., Pahlen, S., Gatz, M., Butler, D. A., Bartels, M., Van Beijsterveldt, T. C. E. M., Craig, J. M., Saffery, R., Freitas, D. L., Maia, J. A., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N. G., Medland, S. E., Montgomery, G. W., Chong, Y., Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Tynelius, P., Lichtenstein, P., Haworth, C. M. A., Plomin, R., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Oncel, S. Y., Aliev, F., Spector, T., Mangino, M., Lachance, G., Baker, L. A., Tuvblad, C., Duncan, G. E., Buchwald, D., Willemsen, G., Rasmussen, F., Jack, H. G., Sørensen, T. I., Boomsma, D. I. & Kaprio, J., 1 Aug 2016, In: The American journal of clinical nutrition. 104, 2, p. 371-379 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

159 Citations (Scopus)

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Tragante, V., van der Laan, S. W., Perry, J. R. B., Kong, A., Ahluwalia, T. S., Albrecht, E., Yerges-Armstrong, L., Atzmon, G., Auro, K. & Ayers, K. & 31 others, Bakshi, A., Ben-Avraham, D., Berger, K., Bergman, A., Bertram, L., Bielak, L. F., Bjornsdottir, G., Bonder, M. J., Broer, L., Bui, M., Barbieri, C., Cavadino, A., Chavarro, J. E., Turman, C., Concas, M. P., Cordell, H. J., Davies, G., Eibich, P., Eriksson, N., Esko, T., Eriksson, J., Falahi, F., Felix, J. F., Fontana, M. A., Franke, L., Gandin, I., Gaskins, A. J., Gieger, C., Lachance, G., Spector, T. D. & BIOS Consortium, Dec 2016, In: Nature Genetics. 48, 12, p. 1462-1472 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

184 Citations (Scopus)

2015

Quantitative variability of 342 plasma proteins in a human twin population

Liu, Y., Buil, A., Collins, B. C., Gillet, L. C. J., Blum, L. C., Cheng, L. Y., Vitek, O., Mouritsen, J., Lachance, G., Spector, T. D., Dermitzakis, E. T. & Aebersold, R., 2015, In: Molecular Systems Biology. 11, 2, 786.

Research output: Contribution to journal › Article › peer-review

259 Citations (Scopus)

The UK10K project identifies rare variants in health and disease

UK10K Consortium, Perry, J. R. B., Brent Richards, J., Clement, G., Hart, D., Hysi, P., Metrustry, S., Hubbard, T., Lachance, G., Small, K. S. & Breen, G., 1 Oct 2015, In: NATURE. 526, p. 82-90 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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739 Citations (Scopus)

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Genevieve Lachance

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