Research output per year
Research output per year
Personal profile
Research interests
Structures, interactions and inhibitor development of IgE network components; Molecular interaction analysis; Inhibitor screening, design and development. Research techniques: Structural biology (NMR and x-ray crystallography); biophysical methods; protein engineering; structure-based drug design; library screening methods. Member of the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma.
Research interests (short)
Structures, interactions and inhibitor development of IgE network components.
Click here for the McDonnell group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Research output
- 5 Article
-
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization
Mitropoulou, A., Ceska, T., Heads, J., Beavil, A., Henry, A. J., McDonnell, J., Sutton, B. & Davies, A. M., 1 Mar 2020, In: Acta Crystallographica Section F:Structural Biology Communications. 76, p. 116-129 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)57 Downloads (Pure) -
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation
Doré, K. A., Kashiwakura, J.-I., McDonnell, J. M., Gould, H. J., Kawakami, T., Sutton, B. J. & Davies, A. M., Jan 2018, In: Molecular Immunology. 93, p. 216-222 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)218 Downloads (Pure) -
Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody
Chen, J.-B., Ramadani, F., Pang, M. O. Y., Beavil, R. L., Holdom, M. D., Mitropoulou, A. N., Beavil, A. J., Gould, H. J., Chang, T. W., Sutton, B. J., McDonnell, J. M. & Davies, A. M., 1 Aug 2018, In: Scientific Reports. 8, 1, 11548.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)205 Downloads (Pure) -
The CD46-Jagged1 interaction is critical for human T(H)1 immunity
Le Friec, G., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S.A.-T., Laing, A., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., Smith, R. A., Drouet, C., Couzi, L., Fremeaux-Bacchi, V., Koehl, J., Waddington, S. N., McDonnell, J. M., Baker, A., Handford, P. A. & Lea, S. M. & 1 others, , Dec 2012, In: Nature Immunology. 13, 12, p. 1213-1221 9 p.Research output: Contribution to journal › Article › peer-review
140 Citations (Scopus) -
BCL-2 family members and the mitochondria in apoptosis
Gross, A., McDonnell, J. M. & Korsmeyer, S. J., 1 Aug 1999, In: Genes and Development. 13, 15, p. 1899-911 13 p.Research output: Contribution to journal › Article › peer-review
3327 Citations (Scopus)