Research output per year
Research output per year
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Dive into the research topics where Mary Holdom is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody
Chen, J.-B., Ramadani, F., Pang, M. O. Y., Beavil, R. L., Holdom, M. D., Mitropoulou, A. N., Beavil, A. J., Gould, H. J., Chang, T. W., Sutton, B. J., McDonnell, J. M. & Davies, A. M., 1 Aug 2018, In: Scientific Reports. 8, 1, 11548.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)211 Downloads (Pure) -
Synthesis and Incorporation into Cyclic Peptides of Tolan Amino Acids and Their Hydrogenated Congeners: Construction of an Array of A-B-loop Mimetics of the C epsilon 3 Domain of Human IgE
Offermann, D. A., McKendrick, J. E., Sejberg, J. J. P., Mo, B., Holdom, M. D., Helm, B. A., Leatherbarrow, R. J., Beavil, A. J., Sutton, B. J. & Spivey, A. C., 6 Apr 2012, In: JOURNAL OF ORGANIC CHEMISTRY. 77, 7, p. 3197 - 3214 18 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
Holdom, M. D., Davies, A. M., Nettleship, J. E., Bagby, S. C., Dhaliwal, B., Girardi, E., Hunt, J., Gould, H. J., Beavil, A. J., McDonnell, J. M., Owens, R. J. & Sutton, B. J., May 2011, In: NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 18, 5, p. 571 - 576 6 p.Research output: Contribution to journal › Article › peer-review
105 Citations (Scopus) -
Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution
Carr, J. L., Sejberg, J. J. P., Saab, F., Holdom, M. D., Davies, A. M., White, A. J. P., Leatherbarrow, R. J., Beavil, A. J., Sutton, B. J., Lindell, S. D. & Spivey, A. C., 2011, In: ORGANIC AND BIOMOLECULAR CHEMISTRY. 9, 19, p. 6814-6824Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether
Carr, J. L., Offermann, D. A., Holdom, M. D., Dusart, P., White, A. J. P., Beavil, A. J., Leatherbarrow, R. J., Lindell, S. D., Sutton, B. J. & Spivey, A. C., 2010, In: CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY. 46, 11, p. 1824 - 1826 3 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus)
Projects
- 4 Finished
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Structure-based discovery of small-molecule IgE inhibitors.
Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Holdom, M. (Co-Investigator) & Williams, G. (Co-Investigator)
1/10/2008 → 29/02/2012
Project: Research
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In silico screening and structural characterization of IgE/FcR1 inhibitators.
Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Holdom, M. (Co-Investigator) & Williams, G. (Co-Investigator)
1/04/2008 → 31/03/2011
Project: Research
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Conformational change in IgE as a target for molecule inhibitor design
Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator) & Holdom, M. (Co-Investigator)
5/12/2005 → 15/01/2008
Project: Research
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Function and x-ray crystallographic analysis of the therapeutically significant interaction between proteinase inhibitors and the secretory acid proteinases of Candida sp
Hamilton, A. (Primary Investigator) & Holdom, M. (Primary Investigator)
Special Trustees of Guys & St Thomas' Hospital
1/10/1999 → 31/03/2001
Project: Research