Research output per year
Research output per year
- 1 - 50 out of 91 results
Search results
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2022
Histone Methylases and Demethylases Regulating Antagonistic Methyl Marks: Changes Occurring in Cancer
Taylor-Papadimitriou, J. & Burchell, J. M., 1 Apr 2022, In: Cells. 11, 7, 1113.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
2021
KDM5B protein expressed in viable and fertile ΔARID mice exhibit no demethylase activity
Jamshidi, S., Catchpole, S., Chen, J., So, C. W. E., Burchell, J., Rahman, M. & Taylor-Papadimitriou, J., 29 Oct 2021, (E-pub ahead of print) In: International Journal of Oncology. 59, 5, 96.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus)4 Downloads (Pure) -
2020
Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype
Beatson, R., Graham, R., Grundland Freile, F., Cozzetto, D., Kannambath, S., Pfeifer, E., Woodman, N., Owen, J., Nuamah, R., Mandel, U., Pinder, S., Gillett, C., Noll, T., Bouybayoune, I., Taylor-Papadimitriou, J. & Burchell, J. M., 1 Dec 2020, In: Communications Biology. 3, 1, 644.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)149 Downloads (Pure) -
O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR
Tajadura-Ortega, V., Gambardella, G., Skinner, A., Halim, A., Van Coillie, J., Schjoldager, K.T.-B. G., Beatson, R., Graham, R., Achkova, D., Taylor-Papadimitriou, J., Ciccarelli, F. D. & Burchell, J. M., 8 Aug 2020, (E-pub ahead of print) In: Glycobiology.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
2018
Latest developments in MUC1 immunotherapy
Taylor-Papadimitriou, J., Burchell, J. M., Graham, R. & Beatson, R., 2018, In: Biochemical Society Transactions. 46, 3, p. 659-668Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
O-linked mucin-type glycosylation in breast cancer
Burchell, J. M., Beatson, R., Graham, R., Taylor-Papadimitriou, J. & Tajadura-Ortega, V., Aug 2018, In: Biochemical Society Transactions. 46, 4, p. 779-788 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)348 Downloads (Pure) -
2017
JARID1/KDM5 demethylases as cancer targets?
Taylor-Papadimitriou, J. & Burchell, J., 2 Jan 2017, In: Expert Opinion on Therapeutic Targets. 21, 1, p. 5-7 3 p.Research output: Contribution to journal › Editorial › peer-review
21 Citations (Scopus) -
2016
Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells
Maher, J., Wilkie, S., Davies, D. M., Arif, S., Picco, G., Julien, S., Foster, J., Burchell, J. & Taylor-Papadimitriou, J., 15 Nov 2016, In: Immunity. 45, 5, p. 945-946 2 p.Research output: Contribution to journal › Letter › peer-review
33 Citations (Scopus) -
The mucin MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9
Beatson, R., Tajadura-Ortega, V., Achkova, D. Y., Picco, G., Tsourouktsoglou, T.-D., Klausing, S., Hillier, M., Maher, J., Noll, T., Crocker, P., Taylor-Papadimitriou, J. & Burchell, J., 1 Nov 2016, In: Nature Immunology. 17, 11, p. 1273-1281Research output: Contribution to journal › Article › peer-review
Open AccessFile263 Citations (Scopus)1302 Downloads (Pure) -
2015
Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma
Karagiannis, P., Villanova, F., Josephs, D. H., Correa, I., Van Hemelrijck, M., Hobbs, C., Saul, L., Egbuniwe, I. U., Tosi, I., Ilieva, K. M., Kent, E., Calonje, E., Harries, M., Fentiman, I., Taylor-Papadimitriou, J., Burchell, J., Spicer, J. F., Lacy, K. E., Nestle, F. O. & Karagiannis, S. N., Nov 2015, In: OncoImmunology. 4, 11, p. e1032492Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Citations (Scopus)263 Downloads (Pure) -
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL
Beatson, R., Maurstud, G., Picco, G., Arulappu, A., Coleman, J. A., Wandell, H. H., Clausen, H., Mandel, U., Taylor-Papadimitriou, J., Sletmoen, M. & Burchell, J. M., 7 May 2015, In: PLOS One. 10, 5, p. 1-21 21 p., e0125994.Research output: Contribution to journal › Article › peer-review
Open Access77 Citations (Scopus) -
2014
Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas
Picco, F., Beatson, R., Taylor-Papadimitriou, J. & Burchell, J., Jul 2014, In: European Journal of Immunology. 44, 7, p. 1947-1955 9 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
2013
Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer
Burford, B., Gentry-Maharaj, A., Graham, R., Allen, D., Pedersen, J., Blixt, O., Fourkala, E.-O. (Editor), Bueti, D., Dawnay, A., Ford, J., Desai, R., Nedelman, A., David, L., Trinder, P., Acres, B., Schwientek, T., Gammerman, A., Reis, C., Silva, L. & Osorio, H. & 10 others, , 28 May 2013, In: BJC: British Journal of Cancer. 108, 10, p. 2045-2055 11 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Citations (Scopus) -
Cancer associated auto-antibodies to MUC1 and MUC4 - A blinded case control study of colorectal cancer in UK Collaborative Trial of Ovarian Cancer Screening
Pedersen, J., Genrty-Maharaj, A., Nostdal, A., Fourkala, E.-O., Dawnay, A., Burnell, M., Zaikin, A., Burchell, J., Taylor-Papadimitriou, J., Clausen, H., Jacobs, I., Menon, U. & Wandall, H., 2013, (E-pub ahead of print) In: International Journal of Cancer. N/A, N/A, p. N/A 9 p., N/A.Research output: Contribution to journal › Article › peer-review
Open Access47 Citations (Scopus) -
2012
Cyclooxygenase-2 Enzyme Induces the Expression of the α-2,3-Sialyltransferase-3 (ST3Gal-I) in Breast Cancer
Sproviero, D., Julien, S., Burford, B., Taylor-Papadimitriou, J. & Burchell, J., 28 Dec 2012, In: Journal of Biological Chemistry. 287, 53, p. 44490-44497 8 p., N/A.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ Proximity Ligation
Pinto, R., Carvalho, A., Conze, T., Magalhaes, A., Picco, G., Burchell, J., Taylor-Papadimitriou, J., Reis, C., Almeida, R., Mandel, U., Clausen, H., Soderberg, O. & David, L., Jul 2012, In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 16, 7, p. 1474-1484 11 p., N/A.Research output: Contribution to journal › Article › peer-review
Open Access70 Citations (Scopus) -
2011
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues
Marcos, N., Bennett, E., Gomes, J., Magalhaes, A., Gomes, C., David, L., Dar, I., Jeanneau, C., DeFrees, S., Krustrup, D., Vogel, L., Kure, E., Burchell, J., Taylor-Papadimitriou, J., Clausen, H., Mandel, U. & Reis, C., Jun 2011, In: Frontiers in Bioscience. 1, 3, p. 1443-1445 3 p., N/A.Research output: Contribution to journal › Article › peer-review
118 Citations (Scopus) -
T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients
Coleman, J. A., Correa, I., Cooper, L., Bohnenkamp, H. R., Poulsom, R., Burchell, J. M. & Taylor-Papadimitriou, J., 1 May 2011, In: International Journal of Cancer. 128, 9, p. 2114 - 2124 11 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Transforming growth factor-β1 is constitutively secreted by Chinese hamster ovary cells and is functional in human cells
Beatson, R., Sproviero, D., Maher, J., Wilkie, S., Taylor-Papadimitriou, J. & Burchell, J. M., Nov 2011, In: BIOTECHNOLOGY AND BIOENGINEERING. 108, 11, p. 2759-2764 6 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
2010
Cancer Biomarkers Defined by Autoantibody Signatures to Aberrant O-Glycopeptide Epitopes
Wandall, H. H., Blixt, O., Tarp, M. A., Pedersen, J. W., Bennett, E. P., Mandel, U., Ragupathi, G., Livingston, P. O., Hollingsworth, M. A., Taylor-Papadimitriou, J., Burchell, J. & Clausen, H., 15 Feb 2010, In: Cancer Research. 70, 4, p. 1306 - 1313 8 p.Research output: Contribution to journal › Article › peer-review
220 Citations (Scopus) -
Expression of Sialyltransferase ST6GalNAc-I and Sialyl-Tn Antigen in Human Gastrointestinal Tissues
Marcos, N., Bennett, E., Gomes, J., Magalhaes, A., Gomes, C., David, L., Dar, I., Jeanneau, C., Defrees, S., Krustrup, D., Vogel, L., Kure, E., Burchell, J., Taylor-Papadimitriou, J., Clausen, H., Mandel, U. & Reis, C., 2010, In: Glycobiology. 20, 11, p. 1499 - 1500 2 p.Research output: Contribution to journal › Meeting abstract
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MUC1 Immunotherapy
Beatson, R., Burchell, J. & Taylor-Papadimitriou, J., May 2010, In: Immunotherapy. 2, 3, p. 305-327 23 p.Research output: Contribution to journal › Article › peer-review
121 Citations (Scopus) -
Over-expression of ST3Gal-I promotes mammary tumorigenesis
Picco, G., Julien, S., Brockhausen, I., Beatson, R., Antonopoulos, A., Haslam, S., Mandel, U., Dell, A., Pinder, S., Taylor-Papadimitriou, J. & Burchell, J., Oct 2010, In: Glycobiology. 20, 10, p. 1241 - 1250 10 p.Research output: Contribution to journal › Article › peer-review
118 Citations (Scopus) -
2009
Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model
Julien, S., Picco, G., Sewell, R., Vercoutter-Edouart, A.-S., Tarp, M., Miles, D., Clausen, H., Taylor-Papadimitriou, J. & Burchell, J. M., 2 Jun 2009, In: BJC: British Journal of Cancer. 100, 11, p. 1746 - 1754 9 p.Research output: Contribution to journal › Article › peer-review
75 Citations (Scopus) -
2008
CHANGES IN POST-TRANSLATIONAL MODIFICATIONS (O-LINKED GLYCOSYLATION) OF BREAST CANCER CAN AFFECT TUMOUR BEHAVIOUR AND IMMUNE RECOGNITION
Julien, S., Picco, G., Colman, J., Beatson, R., Taylor-Papadimitriou, J. & Burchell, J., 2008, In: Anticancer Research. 28, 5C, p. 3225 - 3225 1 p.Research output: Contribution to journal › Meeting abstract
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Development of breast cancer immunotherapy using MUC1-retargeted T lymphocytes
Wilkie, S., Picco, G., Foster, J., Davies, D., Julien, S., Cooper, L., Arif, S., Mather, S., Taylor-Papadimitriou, J., Burchell, J. & Maher, J., 2008, In: Breast Cancer Research. 10, p. S4 1 p., O6.Research output: Contribution to journal › Meeting abstract
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Immunisation with 'naive' syngeneic dendritic cells protects mice from tumour challenge
Grimshaw, M. J., Papazisis, K., Picco, G., Bohnenkamp, H., Noll, T., Taylor-Papadimitriou, J. & Burchell, J., 26 Feb 2008, In: BJC: British Journal of Cancer. 98, 4, p. 784 - 791 8 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
Grimshaw, M. J., Cooper, L., Papazisis, K., Coleman, J. A., Bohnenkamp, H. R., Chiapero-Stanke, L., Taylor-Papadimitriou, J. & Burchell, J. M., 9 Jun 2008, In: Breast Cancer Research. 10, 3, R52.Research output: Contribution to journal › Article › peer-review
286 Citations (Scopus) -
Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
Wilkie, S., Picco, G., Foster, J., Davies, D. M., Julien, S., Cooper, L., Arif, S., Mather, S. J., Taylor-Papadimitriou, J., Burchell, J. M. & Maher, J., 1 Apr 2008, In: Journal of Immunology. 180, 7, p. 4901-4909 9 p.Research output: Contribution to journal › Article › peer-review
289 Citations (Scopus) -
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation
Dey, B. K., Stalker, L., Schnerch, A., Bhatia, M., Taylor-Papadimitriou, J. & Wynder, C., Sept 2008, In: Molecular and Cellular Biology. 28, 17, p. 5312 - 5327 16 p.Research output: Contribution to journal › Article › peer-review
110 Citations (Scopus) -
Understanding and exploiting changes in O-linked glycosylation in breast cancer
Julien, S., Coleman, J., Picco, G., Beatson, R., Taylor-Papadimitriou, J. & Burchell, J., 2008, In: Breast Cancer Research. 10, p. 29 1 p.Research output: Contribution to journal › Meeting abstract
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2007
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases
Barrett, A., Santangelo, S., Tan, K., Catchpole, S., Roberts, K., Spencer-Dene, B., Hall, D., Scibetta, A., Burchell, J., Verdin, E., Freemont, P. & Taylor-Papadimitriou, J., 15 Jul 2007, In: International Journal of Cancer. 121, 2, p. 265 - 275 11 p.Research output: Contribution to journal › Article › peer-review
83 Citations (Scopus) -
Functional analysis of the transcription repressor PLU-1/JARID1B
Scibetta, A., Santangelo, S., Coleman, J., Hall, D., Chaplin, T., Copier, J., Catchpole, S., Burchell, J. & Taylor-Papadimitriou, J., Oct 2007, In: Molecular and Cellular Biology. 27, 20, p. 7220 - 7235 16 p.Research output: Contribution to journal › Article › peer-review
114 Citations (Scopus) -
Sialyl-lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: A mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I
Julien, S., Grimshaw, M. J., Sutton-Smith, M., Coleman, J., Morris, H. R., Dell, A., Taylor-Papadimitriou, J. & Burche, J. M., 2007, In: Journal of Immunology. 179, 9, p. 5701 - 5710 10 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Sialyl-Lewisx on P-Selectin Glycoprotein Ligand-1 Is Regulated during Differentiation and Maturation of Dendritic Cells: A Mechanism Involving the Glycosyltransferases C2GnT1 and ST3Gal I1
Julien, S., Grimshaw, M. J., Sutton-Smith, M., Coleman, J., Morris, H. R., Dell, A., Taylor-Papadimitriou, J. & Burchell, J. M., 2007, In: Journal of Immunology. 179, 9, p. 5701 - 5710 10 p.Research output: Contribution to journal › Article › peer-review
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Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses
Bohnenkamp, H. R., Papazisis, K. T., Burchell, J. M. & Taylor-Papadimitriou, J., Jun 2007, In: Cellular Immunology. 247, 2, p. 72 - 84 13 p.Research output: Contribution to journal › Article › peer-review
84 Citations (Scopus) -
Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic Cells
Napoletano, C., Rughetti, A., Agervig Tarp, M. P., Coleman, J., Picco, G., Sale, P., Denda-Nagai, K., Irimura, T., Mandel, U., Clausen, H., Frati, L., Taylor-Papadimitriou, J., Burchell, J. & Nuti, M., 1 Sept 2007, In: Cancer Research. 67, 17, p. 8358 - 8367 10 p.Research output: Contribution to journal › Article › peer-review
118 Citations (Scopus) -
2006
Characterisation of integrin and anchorage dependence in mammary epithelial cells following c-erbB2-induced epithelial-mesenchymal transition
Jenndahl, L., Taylor-Papadimitriou, J. & Backstrom, D., 2006, In: Tumour Biology. 27, p. 50 - 58 9 p.Research output: Contribution to journal › Article › peer-review
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Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance
Sorensen, A. L., Reis, C. A., Tarp, M. A., Mandel, U., Ramachandran, K., Sankaranarayanan, V., Schwientek, T., Graham, R., Taylor-Papadimitriou, J., Hollingsworth, M. A., Burchell, J. & Clausen, H., Feb 2006, In: Glycobiology. 16, 2, p. 96 - 107 12 p.Research output: Contribution to journal › Article › peer-review
223 Citations (Scopus) -
Development of breast cancer immunotherapy using MUC1 retargeted T lymphocytes
Wilkie, S., Brenner, M. K., Taylor-Papadimitriou, J., Burchell, J. & Maher, J., 2006, In: Breast Cancer Research. 8, Suppl 2, p. S17 - S18 P38.Research output: Contribution to journal › Meeting abstract
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Functional analysis of the breast cancer associated transcriptional repressor PLU-1/JARID1B
Taylor-Papadimitriou, J., Barrett, A., Santangelo, S., Catchpole, S., Coleman, J., Hall, D., Burchell, J. & Scibetta, A. G., 2006, In: Breast Cancer Research. 8, p. S8 - S8Research output: Contribution to journal › Meeting abstract
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The ST6GalNAc-I sialyltransferase localizes throughout the golgi and is responsible for the synthesis of the tumor-associated Sialyl-Tn O-glycan in human breast cancer
Sewell, R., Backstrom, M., Dalziel, M., Gschmeissner, S., Karlsson, H., Noll, T., Gatgens, J., Clausen, H., Hansson, G. C., Burchell, J. & Taylor-Papadimitriou, J., 10 Feb 2006, In: Journal of Biological Chemistry. 281, 6, p. 3586 - 3594 9 p.Research output: Contribution to journal › Article › peer-review
206 Citations (Scopus) -
2005
A modified caspase gene is an effective adjuvant for a DNA vaccine containing a recombinant gene for the tumour-associated antigen MUC1
Townshend, C., Stewart, L., Picco, G., Burchell, J., Taylor-Papadimitriou, J. & Snary, D., 2005, In: Immunology. 116, p. 34 - 34 1 p.Research output: Contribution to journal › Meeting abstract
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Development of a chimeric antigen receptor (CAR) to re-target human T-cells to MUC1
Wilkie, S., Brenner, M. K., Taylor-Papadimitriou, J., Burchell, J. & Maher, J., 2005, In: Immunology. 116, p. 39 - 40 2 p.Research output: Contribution to journal › Meeting abstract
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Gene expression changes induced by a recombinant E1(-)/E3(-) adenovirus type 5 vector in human mammary epithelial cells
Scibetta, A. G., Copier, J., Barrett, A., Chaplin, T. & Taylor-Papadimitriou, J., Nov 2005, In: Intervirology. 48, 6, p. 350 - 361 12 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells
Rughetti, A., Pellicciotta, I., Biffoni, M., Backstrom, M., Link, T., Bennet, E. P., Clausen, H., Noll, T., Hansson, G. C., Burchelll, J. M., Frati, L., Taylor-Papadimitriou, J. & Nuti, M., 15 Jun 2005, In: Journal of Immunology. 174, 12, p. 7764 - 7772 9 p.Research output: Contribution to journal › Article › peer-review
76 Citations (Scopus) -
Recombinant tumour associated MUC1 impairs differentiation and function of dendritic cells.
Rughetti, A., Pellicciotta, I., Biffoni, M., Backstrom, M., Link, T., Noll, T., Hansson, G. C., Clausen, H., Burchell, J., Taylor-Papadimitriou, J. & Nuti, M., 2005, In: Journal of Immunology. 174, 12, p. 7764 - 7772 9 p.Research output: Contribution to journal › Article › peer-review
76 Citations (Scopus) -
Responses of human T cells to peptides flanking the tandem repeat and overlapping the signal sequence of MUC1
Correa, I., Plunkett, T., Coleman, J., Galani, E., Windmill, E., Burchell, J. M. & Taylor-Papadimitriou, J., 10 Jul 2005, In: International Journal of Cancer. 115, 5, p. 760 - 768 9 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2004
Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells
Bohnenkamp, H. R., Burchell, J. M., Taylor-Papadimitriou, J. & Noll, T., Nov 2004, In: Journal of Immunological Methods. 294, 1-2, p. 67 - 80 14 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo
Catteau, A., Rosewell, I., Solomon, E. & Taylor-Papadimitriou, J., Jul 2004, In: International Journal of Oncology. 25, 1, p. 5 - 16 12 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)