Kourosh Rasekh Ahmadi

Pharmacogenomics (PGx) and Nutrigenomics (NGx) deal with how variations in the human genome affect response to common used medications or dietary factors. The principle aim of PGx or NGx is to develop rational means to optimise drug therapy or nutritional supplementation, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects.<br /> My group undertakes a wide variety of research including:<br /> <br /> 1. The study of genetic and environmental factors that influence drug response or response to nutritional supplementation using the classical twin model<br /> 2. Genomic epidemiology of adverse drug reactions (ADRs) including immediate allergy to beta-lactam antibiotics, drug-induced peripheral neuropathy &amp; SLE etc...<br />3. Candidate gene/pathway as well as genomewide association studies of baseline vitamin and mineral levels as well as key liver enzymes important in drug absorption, distribution, metabolism and elimination<br />4. The application of System biology tools &ndash; genomics, Transcriptomics, proteomics and metabonomics &ndash; to study induction &amp; inhibition in healthy human volunteers.<br /> <br />

Pharmacogenomics, pertubation studies, Population Genetics, Genomic Epidemiology