Search results

• 2020

  Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

  Sawitzki, B., Harden, P., Reinke, P., Moreau, A., Hutchinson, J. A., Game, D. S., Tang, Q., Guinan, E., Battaglia, M., Burlingham, W. J., Roberts, I., Streitz, M., Josien, R., Böger, C. A., Scotta, C., Markmann, J. F., Hester, J., Juerchott, K., Braudeau, C. & James, B. & 41 others, Contreras-Ruiz, L., van der Net, J. B., Bergler, T., Caldara, R., Petchey, W., Edinger, M., Dupas, N., Kapinsky, M., Mutzbauer, I., Otto, N. M., Ollinger, R., Hernandez Fuentes, M., Issa, F., Ahrens, N., Meyenberg, C., Karitzky, S., Kunzendorf, U., Knechtle, S. J., Grinyo, J., Morris, P. J., Brent, L., Bushell, A., Turka, L. A., Bluestone, J. A., Lechler, R., Schlitt, H. J., Cuturi, M. C., Schlickeiser, S., Friend, P. J., Miloud, T., Scheffold, A., Secchi, A., Crisalli, K., Kang, S.-M., Hilton, R., Banas, B., Blancho, G., Volk, H.-D., Lombardi, G., Wood, K. & Geissler, E. K., 23 May 2020, In: The Lancet. 395, 10237, p. 1627-1639

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Analysis 100%
  • Regulatory Cell 100%
  • Arm 100%
  • Cell Therapy 100%
  • Kidney Transplantation 100%
  275 Citations (Scopus)

  848 Downloads (Pure)
• 2016

  Biomarkers of tolerance in kidney transplantation – are we predicting tolerance or response to immunosuppressive treatment?

  Rebollo-Mesa, I., Nova-Lamperti, E., Mobillo, P., Runglall, M., Christakoudi, S., Norris, S., Smallcombe, N., Kamra, Y., Hilton, R., Consortium, I. O. T. E., Bhandari, S., Baker, R., Berglund, D., Carr, S., Game, D., Griffin, S., Kalra, P. A., Lewis, R., Mark, P. B. & Marks, S. & 12 others, Macphee, I., McKane, W., Mohaupt, M. G., Pararajasingam, R., Kon, S. P., Serón, D., Sinha, M., Tucker, B., Viklický, O., Lechler, R. I., Lord, G. M. & Hernandez-Fuentes, M. P., 21 Jun 2016, (E-pub ahead of print) In: American Journal of Transplantation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immunosuppressive Drug 100%
  • B Cell 28%
  • Gene Expression Assay 28%
  89 Citations (Scopus)

  207 Downloads (Pure)

• IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses

  Nova Lamperti, E. A., Fanelli, G., Becker, P. D., Chana, P., Elgueta Rebolledo, R. A., Dodd, P., Lord, G. M., Lombardi, G. & Hernandez Fuentes, M. P., 22 Jan 2016, In: Scientific Reports. 6, p. 20044 20044.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T-Helper Cell 100%
  • T Cell Proliferation 37%
  • Adoptive Immunity 12%
  • T Cell Activation 12%
  • Tumor Necrosis Factor 12%
  64 Citations (Scopus)

  220 Downloads (Pure)
• 2014

  Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells

  Cherukuri, A., Rothstein, D. M., Clark, B., Carter, C. R., Davison, A., Hernandez-Fuentes, M., Hewitt, E., Salama, A. D. & Baker, R. J., 1 Jul 2014, In: Journal of the American Society of Nephrology : JASN. 25, 7, p. 1575-1585 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Necrosis Factor 100%
  • Regulatory B Cells 100%
  • B Cell 63%
  • Memory B Cell 18%
  • Cytokine Polarization 18%
  121 Citations (Scopus)
• 2010

  Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

  Sagoo, P., Perucha, E., Sawitzki, B., Tomiuk, S., Stephens, D. A., Miqueu, P., Chapman, S., Craciun, L., Sergeant, R., Brouard, S., Rovis, F., Jimenez, E., Ballow, A., Giral, M., Rebollo-Mesa, I., Le Moine, A., Braudeau, C., Hilton, R., Gerstmayer, B. & Bourcier, K. & 14 others, Sharif, A., Krajewska, M., Lord, G. M., Roberts, I., Goldman, M., Wood, K. J., Newell, K., Seyfert-Margolis, V., Warrens, A. N., Janssen, U., Volk, H.-D., Soulillou, J.-P., Hernandez-Fuentes, M. P. & Lechler, R. I., 1 Jun 2010, In: Journal of Clinical Investigation. 120, 6, p. 1848 - 1861 14 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Helper Cell 100%
  • B Cell 50%
  • Immunosuppressive Drug 50%
  • Immune Tolerance 50%
  458 Citations (Scopus)

• Identification of a B cell signature associated with renal transplant tolerance in humans

  Newell, K. A., Asare, A., Kirk, A. D., Gisler, T. D., Bourcier, K., Suthanthiran, M., Burlingham, W. J., Marks, W. H., Sanz, I., Lechler, R. I., Hernandez-Fuentes, M. P., Turka, L. A. & Seyfert-Margolis, V. L., 1 Jun 2010, In: Journal of Clinical Investigation. 120, 6, p. 1836 - 1847 12 p.

  Research output: Contribution to journal › Article › peer-review

  • B Cell 100%
  • Immunosuppression 66%
  • Immunosuppressive Drug 16%
  • Peripheral Blood Lymphocyte 16%
  • Alloimmunity 16%
  592 Citations (Scopus)
• 2007

  Allorecognition and the alloresponse: clinical implications

  Afzali, B., Lechler, R. I. & Hernandez Fuentes, M., Jun 2007, In: Tissue Antigens. 69, 6, p. 545 - 556 12 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allorecognition 100%
  • Natural Killer Cell 33%
  • Bone Marrow Transplantation 33%
  121 Citations (Scopus)