Research output per year
Research output per year
Personal profile
Research interests
The Vascular Biology Section is a basic science research unit. It undertakes a wide range of research in the field of cardiovascular diseases with the broad objective of improving the understanding of molecular mechanisms in the pathogenesis and the treatment of cardiovascular disease. The overarching aim of our study is to elucidate the molecular mechanisms underlying cardiovascular diseases, especially atherosclerosis. Our task is to bridge the gap between basic science research and its application through cardiology and cardiac surgery. In keeping with this, several research projects are carried out in the Unit as follows: <br />1) Stem/progenitor cells in atherosclerosis <br />2) Proteomics<br />3) Mechanical stress-initiated signalling.
Research interests (short)
Stem cells; pathogenesis of atherosclerosis; vascular biology; animal models; proteomics; gene expression.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm
Shao, F., Miao, Y., Zhang, Y., Han, L., Ma, X., Deng, J., Jiang, C., Kong, W., Xu, Q., Feng, J. & Wang, X., 1 Sept 2020, In: Cardiovascular Research. 116, 11, p. 1897-1909 13 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts
Qin, K., Wang, F., Simpson, R. M. L., Zheng, X., Wang, H., Hu, Y., Gao, Z., Xu, Q. & Zhao, Q., Oct 2020, In: Biomaterials. 257, 120226.Research output: Contribution to journal › Article › peer-review
61 Citations (Scopus) -
Impact of Local Alloimmunity and Recipient Cells in Transplant Arteriosclerosis
Cai, J., Deng, J., Gu, W., Ni, Z., Liu, Y., Kamra, Y., Saxena, A., Hu, Y., Yuan, H., Xiao, Q., Lu, Y. & Xu, Q., 25 Sept 2020, In: Circulation Research. 127, 8, p. 974-993 20 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus) -
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment
Miao, Y., Zhao, Y., Han, L., Ma, X., Deng, J., Yang, J., Lü, S., Shao, F., Kong, W., Wang, W., Xu, Q., Wang, X. & Feng, J., 1 Jan 2020, (Accepted/In press) In: Cellular and Molecular Life Sciences.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE−/− mice by metabolic suppression
Lü, S. L., Dang, G. H., Deng, J. C., Liu, H. Y., Liu, B., Yang, J., Ma, X. L., Miao, Y. T., Jiang, C. T., Xu, Q. B., Wang, X. & Feng, J., 1 Jan 2020, In: ACTA PHARMACOLOGICA SINICA. 41, 1, p. 47-55 9 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus)
Projects
- 52 Finished
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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SMARTEN - Small Artery European Training Network
Xu, Q. (Primary Investigator)
1/10/2017 → 30/09/2021
Project: Research
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Precise genetic lineage tracing & gene targeting for cell origin in fate studies in atherosclerosis
Xu, Q. (Primary Investigator)
1/10/2017 → 30/09/2020
Project: Research
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The role of XBP1-mediated novel type IV collagen isoform in progenitor cell migration
Zeng, L. (Primary Investigator) & Xu, Q. (Co-Investigator)
1/09/2016 → 30/06/2019
Project: Research
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BHF Chair of Cardiovascular Science
Xu, Q. (Primary Investigator)
1/07/2016 → 30/06/2021
Project: Research