Research output per year
Research output per year
Personal profile
Research interests (short)
Identification of therapeutic targets for heart failure; cardiomyocyte death; mitochondria
Research interests
Heart failure can be defined as “cardiomyocyte-deficiency syndrome”. Three types of cell death, namely apoptosis, necrosis and autophagic death, have been reported. Various types of cardiomyocyte death may play an important role in the development and progression of heart failure. Our research aims to (a) characterize various types of cardiomyocyte death and test the above hypothesis, (b) elucidate underlying mechanisms that are involved (c) examine whether the regulation of cell death may be a novel therapeutic approach to treat patients with heart failure. Our research involves the application of integrated in vivo physiological studies, molecular, cell biological, imaging and signalling studies using gene-targeting mice to investigate the role of cardiomyocyte death in development of heart failure.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload
Akazawa, Y., Taneike, M., Ueda, H., Kitazume-Taneike, R., Murakawa, T., Sugihara, R., Yorifuji, H., Nishida, H., Mine, K., Hioki, A., Omiya, S., Nakayama, H., Yamaguchi, O., Yoshimori, T., Sakata, Y. & Otsu, K., 7 Jan 2022, (E-pub ahead of print) In: Scientific Reports. 12, 1, 41.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
Ishizuka, M., Harada, M., Nomura, S., Ko, T., Ikeda, Y., Guo, J., Bujo, S., Yanagisawa-Murakami, H., Satoh, M., Yamada, S., Kumagai, H., Motozawa, Y., Hara, H., Fujiwara, T., Sato, T., Takeda, N., Takeda, N., Otsu, K., Morita, H. & Toko, H. & 1 others, , Dec 2021, In: Scientific Reports. 11, 1, 3426.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, Jan 2021, In: Autophagy. 17, 1, p. 1-382 382 p.Research output: Contribution to journal › Article › peer-review
1609 Citations (Scopus) -
Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
Ito, J., Omiya, S., Rusu, M.-C., Ueda, H., Murakawa, T., Tanada, Y., Abe, H., Nakahara, K., Asahi, M., Taneike, M., Nishida, K., Shah, A. & Otsu, K., 2 Feb 2021, In: eLife. 10, p. 1-23 23 p., e62174.Research output: Contribution to journal › Article › peer-review
Open AccessFile89 Citations (Scopus)59 Downloads (Pure) -
NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6Chi monocytes in pressure-overloaded hearts
Abe, H., Tanada, Y., Omiya, S., Podaru, M.-N., Murakawa, T., Shah, A., Ito, J., Ono, M., Conway, S. J. & Otsu, K., 12 Oct 2021, In: Science Signaling. 14, 704, p. eabe4932Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)73 Downloads (Pure)
Projects
- 12 Finished
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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The involvement of FKBP38-mediated proteotoxicity in the genesis of heart failure
Otsu, K. (Primary Investigator)
1/10/2017 → 30/09/2020
Project: Research
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Non-apoptotic cell death in heart failure
Otsu, K. (Primary Investigator)
3/01/2017 → 30/04/2022
Project: Research
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King’s NMR Facility for structural biology, metabolic profiling and drug discovery
Conte, M. (Primary Investigator), Avkiran, M. (Co-Investigator), Blower, P. (Co-Investigator), Dodding, M. (Co-Investigator), Eaton, P. (Co-Investigator), Gautel, M. (Co-Investigator), Irving, M. (Co-Investigator), Malim, M. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Otsu, K. (Co-Investigator), Pastore, A. (Co-Investigator), Pfuhl, M. (Co-Investigator), Poston, L. (Co-Investigator), Shah, A. (Co-Investigator), Shanahan, C. (Co-Investigator), Shattock, M. (Co-Investigator) & Williamson, C. (Co-Investigator)
BHF British Heart Foundation, Wellcome Trust
1/01/2017 → 31/12/2021
Project: Research
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Mitochondrial DNA degradation and sterile inflammation in the heart (RAMBO)
Otsu, K. (Primary Investigator)
1/09/2016 → 31/08/2021
Project: Research