Breen, G., Webb, B. T., Butler, A. W., van den Oord, E. J. C. G., Tozzi, F., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Cohen-Woods, S., Perry, J., Galwey, N. W., Upmanyu, R., Craig, I., Lewis, C. M., Ng, M., ... McGuffin, P. (2011). A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. The American Journal of Psychiatry, 168(8), 840 - 847. https://doi.org/10.1176/appi.ajp.2011.10091342
Breen, Gerome ; Webb, Bradley Todd ; Butler, Amy W et al. / A genome-wide significant linkage for severe depression on chromosome 3 : the depression network study. In: The American Journal of Psychiatry. 2011 ; Vol. 168, No. 8. pp. 840 - 847.
@article{962e38cb4d7846099286cb3da61f835a,
title = "A genome-wide significant linkage for severe depression on chromosome 3: the depression network study",
abstract = "Objective: The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample. Method: The authors conducted a genome-wide linkage analysis of 839 families consisting of 971 affected sibling pairs with severe recurrent major depression, comprising waves I and II of the Depression Network Study cohort. In addition to examining affected status, linkage analyses in the full data set were performed using diagnoses restricted by impairment severity, and association mapping of hits in a large case-control data set was attempted. Results: The authors identified genome-wide significant linkage to chromosome 3p25-26 when the diagnoses were restricted by severity, which was a maximum LOD score of 4.0 centered at the linkage marker D3S1515. The linkage signal identified was genome-wide significant after correction for the multiple phenotypes tested, although subsequent association mapping of the region in a genome-wide association study of a U. K. depression sample did not provide significant results. Conclusions: The authors report a genome-wide significant locus for depression that implicates genes that are highly plausible for involvement in the etiology of recurrent depression. Despite the fact that association mapping in the region was negative, the linkage finding was replicated by another group who found genome-wide-significant linkage for depression in the same region. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication.",
author = "Gerome Breen and Webb, {Bradley Todd} and Butler, {Amy W} and {van den Oord}, {Edwin J C G} and Federica Tozzi and Nick Craddock and Mike Gill and Ania Korszun and Wolfgang Maier and Lefkos Middleton and Ole Mors and Owen, {Michael J} and Sarah Cohen-Woods and Julia Perry and Galwey, {Nicholas W} and Ruchi Upmanyu and Ian Craig and Lewis, {Cathryn M} and Mandy Ng and Shyama Brewster and Martin Preisig and Marcella Rietschel and Lisa Jones and Jo Knight and John Rice and Pierandrea Muglia and Farmer, {Anne E} and Peter McGuffin",
year = "2011",
month = aug,
doi = "10.1176/appi.ajp.2011.10091342",
language = "English",
volume = "168",
pages = "840 -- 847",
journal = "The American Journal of Psychiatry",
issn = "1535-7228",
publisher = "American Psychiatric Publishing Inc.",
number = "8",
}
Breen, G, Webb, BT, Butler, AW, van den Oord, EJCG, Tozzi, F, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Mors, O, Owen, MJ, Cohen-Woods, S, Perry, J, Galwey, NW, Upmanyu, R, Craig, I, Lewis, CM, Ng, M, Brewster, S, Preisig, M, Rietschel, M, Jones, L, Knight, J, Rice, J, Muglia, P, Farmer, AE & McGuffin, P 2011, 'A genome-wide significant linkage for severe depression on chromosome 3: the depression network study', The American Journal of Psychiatry, vol. 168, no. 8, pp. 840 - 847. https://doi.org/10.1176/appi.ajp.2011.10091342
A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. /
Breen, Gerome; Webb, Bradley Todd
; Butler, Amy W et al.
In:
The American Journal of Psychiatry, Vol. 168, No. 8, 08.2011, p. 840 - 847.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - A genome-wide significant linkage for severe depression on chromosome 3
T2 - the depression network study
AU - Breen, Gerome
AU - Webb, Bradley Todd
AU - Butler, Amy W
AU - van den Oord, Edwin J C G
AU - Tozzi, Federica
AU - Craddock, Nick
AU - Gill, Mike
AU - Korszun, Ania
AU - Maier, Wolfgang
AU - Middleton, Lefkos
AU - Mors, Ole
AU - Owen, Michael J
AU - Cohen-Woods, Sarah
AU - Perry, Julia
AU - Galwey, Nicholas W
AU - Upmanyu, Ruchi
AU - Craig, Ian
AU - Lewis, Cathryn M
AU - Ng, Mandy
AU - Brewster, Shyama
AU - Preisig, Martin
AU - Rietschel, Marcella
AU - Jones, Lisa
AU - Knight, Jo
AU - Rice, John
AU - Muglia, Pierandrea
AU - Farmer, Anne E
AU - McGuffin, Peter
PY - 2011/8
Y1 - 2011/8
N2 - Objective: The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample.
Method: The authors conducted a genome-wide linkage analysis of 839 families consisting of 971 affected sibling pairs with severe recurrent major depression, comprising waves I and II of the Depression Network Study cohort. In addition to examining affected status, linkage analyses in the full data set were performed using diagnoses restricted by impairment severity, and association mapping of hits in a large case-control data set was attempted.
Results: The authors identified genome-wide significant linkage to chromosome 3p25-26 when the diagnoses were restricted by severity, which was a maximum LOD score of 4.0 centered at the linkage marker D3S1515. The linkage signal identified was genome-wide significant after correction for the multiple phenotypes tested, although subsequent association mapping of the region in a genome-wide association study of a U. K. depression sample did not provide significant results.
Conclusions: The authors report a genome-wide significant locus for depression that implicates genes that are highly plausible for involvement in the etiology of recurrent depression. Despite the fact that association mapping in the region was negative, the linkage finding was replicated by another group who found genome-wide-significant linkage for depression in the same region. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication.
AB - Objective: The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample.
Method: The authors conducted a genome-wide linkage analysis of 839 families consisting of 971 affected sibling pairs with severe recurrent major depression, comprising waves I and II of the Depression Network Study cohort. In addition to examining affected status, linkage analyses in the full data set were performed using diagnoses restricted by impairment severity, and association mapping of hits in a large case-control data set was attempted.
Results: The authors identified genome-wide significant linkage to chromosome 3p25-26 when the diagnoses were restricted by severity, which was a maximum LOD score of 4.0 centered at the linkage marker D3S1515. The linkage signal identified was genome-wide significant after correction for the multiple phenotypes tested, although subsequent association mapping of the region in a genome-wide association study of a U. K. depression sample did not provide significant results.
Conclusions: The authors report a genome-wide significant locus for depression that implicates genes that are highly plausible for involvement in the etiology of recurrent depression. Despite the fact that association mapping in the region was negative, the linkage finding was replicated by another group who found genome-wide-significant linkage for depression in the same region. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication.
U2 - 10.1176/appi.ajp.2011.10091342
DO - 10.1176/appi.ajp.2011.10091342
M3 - Article
C2 - 21572164
SN - 1535-7228
VL - 168
SP - 840
EP - 847
JO - The American Journal of Psychiatry
JF - The American Journal of Psychiatry
IS - 8
ER -
Breen G, Webb BT, Butler AW, van den Oord EJCG, Tozzi F, Craddock N et al. A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. The American Journal of Psychiatry. 2011 Aug;168(8):840 - 847. doi: 10.1176/appi.ajp.2011.10091342