TY - JOUR
T1 - B cells and immunosenescence: A focus on IgG(+)IgD(-)CD27(-) (DN) B cells in aged humans
AU - Bulati, Matteo
AU - Buffa, Silvio
AU - Candore, Giuseppina
AU - Caruso, Calogero
AU - Dunn-Walters, Deborah K.
AU - Pellicano, Mariavaleria
AU - Wu, Yu-Chang Bryan
AU - Romano, Giuseppina Colonna
PY - 2011/4
Y1 - 2011/4
N2 - Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly. (C) 2010 Elsevier B.V. All rights reserved.
AB - Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly. (C) 2010 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.arr.2010.12.002
DO - 10.1016/j.arr.2010.12.002
M3 - Literature review
VL - 10
SP - 274
EP - 284
JO - AGEING RESEARCH REVIEWS
JF - AGEING RESEARCH REVIEWS
IS - 2
ER -
